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    Aff3 AF4/FMR2 family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16764, updated on 7-Aug-2018

    Summary

    Official Symbol
    Aff3provided by MGI
    Official Full Name
    AF4/FMR2 family, member 3provided by MGI
    Primary source
    MGI:MGI:106927
    See related
    Ensembl:ENSMUSG00000037138 Vega:OTTMUSG00000019698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Laf4; LAF-4; A730046J16; 3222402O04Rik
    Expression
    Broad expression in thymus adult (RPKM 9.9), spleen adult (RPKM 7.6) and 19 other tissues See more
    Orthologs

    Genomic context

    See Aff3 in Genome Data Viewer
    Location:
    1 B; 1 16.58 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (38175393..38628333, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (38234172..38721800, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene REV1, DNA directed polymerase Neighboring gene predicted gene 5099 Neighboring gene predicted gene 16150 Neighboring gene nucleoside diphosphate kinase, mitochondrial pseudogene Neighboring gene predicted gene, 34596 Neighboring gene LON peptidase N-terminal domain and ring finger 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    embryonic hindlimb morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    ELL-EAF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    AF4/FMR2 family member 3
    Names
    lymphoid nuclear protein 4
    lymphoid nuclear protein related to AF4
    protein LAF-4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290814.1NP_001277743.1  AF4/FMR2 family member 3

      Status: VALIDATED

      Source sequence(s)
      AC138386, AK014322, AK046648, BQ443842, BU056443, CF533692
      Consensus CDS
      CCDS69884.1
      UniProtKB/TrEMBL
      D3YYI6
      Related
      ENSMUSP00000092637.2, OTTMUSP00000021301, ENSMUST00000095027.8, OTTMUST00000047164
      Conserved Domains (1) summary
      pfam05110
      Location:231223
      AF-4; AF-4 proto-oncoprotein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      38175393..38628333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238446.2XP_011236748.1  AF4/FMR2 family member 3 isoform X3

      Conserved Domains (1) summary
      pfam05110
      Location:871271
      AF-4; AF-4 proto-oncoprotein
    2. XM_011238444.2XP_011236746.1  AF4/FMR2 family member 3 isoform X2

      Conserved Domains (1) summary
      pfam05110
      Location:871286
      AF-4; AF-4 proto-oncoprotein
    3. XM_011238443.2XP_011236745.1  AF4/FMR2 family member 3 isoform X1

      Conserved Domains (1) summary
      pfam05110
      Location:871287
      AF-4; AF-4 proto-oncoprotein
    4. XM_011238447.2XP_011236749.1  AF4/FMR2 family member 3 isoform X5

      Conserved Domains (1) summary
      pfam05110
      Location:871260
      AF-4; AF-4 proto-oncoprotein
    5. XM_006495737.3XP_006495800.1  AF4/FMR2 family member 3 isoform X4

      Conserved Domains (1) summary
      pfam05110
      Location:621262
      AF-4; AF-4 proto-oncoprotein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010678.2: Suppressed sequence

      Description
      NM_010678.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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