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    Kifap3 kinesin-associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 16579, updated on 5-Aug-2018

    Summary

    Official Symbol
    Kifap3provided by MGI
    Official Full Name
    kinesin-associated protein 3provided by MGI
    Primary source
    MGI:MGI:107566
    See related
    Ensembl:ENSMUSG00000026585 Vega:OTTMUSG00000018234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAP3; SMAP; KAP-3
    Summary
    The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
    Expression
    Broad expression in CNS E18 (RPKM 36.2), cortex adult (RPKM 29.0) and 15 other tissues See more
    Orthologs

    Genomic context

    See Kifap3 in Genome Data Viewer
    Location:
    1; 1 H2.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (163762138..163917107)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (165709810..165847231)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene methyltransferase like 11B Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene cDNA sequence BC055324 Neighboring gene methyltransferase like 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    intraciliary transport particle B binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    microtubule-based process IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of calcium-dependent cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin II complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinesin II complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinesin II complex ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-associated protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305643.1NP_001292572.1  kinesin-associated protein 3 isoform KAP3A

      See identical proteins and their annotated locations for NP_001292572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (KAP3A, PMID:8710890).
      Source sequence(s)
      AK013954, AK133957, BC040362, BU701040
      Consensus CDS
      CCDS78729.1
      UniProtKB/Swiss-Prot
      P70188
      UniProtKB/TrEMBL
      Q3UZA5, Q9CRX5
      Related
      ENSMUSP00000027877.5, OTTMUSP00000019807, ENSMUST00000027877.6, OTTMUST00000044068
      Conserved Domains (2) summary
      cd00020
      Location:578662
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05804
      Location:13720
      KAP; Kinesin-associated protein (KAP)
    2. NM_010629.3NP_034759.1  kinesin-associated protein 3 isoform KAP3B

      See identical proteins and their annotated locations for NP_034759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (KAP3B, PMID:8710890) is shorter and has a distinct C-terminus, compared to KAP3A.
      Source sequence(s)
      AK013954, BC040362, BU701040
      Consensus CDS
      CCDS35751.1
      UniProtKB/Swiss-Prot
      P70188
      UniProtKB/TrEMBL
      Q9CRX5
      Related
      ENSMUSP00000076830.5, OTTMUSP00000019806, ENSMUST00000077642.11, OTTMUST00000044067
      Conserved Domains (2) summary
      cd00020
      Location:578662
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05804
      Location:13720
      KAP; Kinesin-associated protein (KAP)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      163762138..163917107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496681.3XP_006496744.1  kinesin-associated protein 3 isoform X2

      Conserved Domains (2) summary
      cd00020
      Location:594678
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05804
      Location:29736
      KAP; Kinesin-associated protein (KAP)
    2. XM_006496679.3XP_006496742.1  kinesin-associated protein 3 isoform X1

      Conserved Domains (2) summary
      cd00020
      Location:594678
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05804
      Location:29736
      KAP; Kinesin-associated protein (KAP)
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