Format

Send to:

Choose Destination
    • Showing Current items.

    Kcnk2 potassium channel, subfamily K, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16526, updated on 18-Sep-2018

    Summary

    Official Symbol
    Kcnk2provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 2provided by MGI
    Primary source
    MGI:MGI:109366
    See related
    Ensembl:ENSMUSG00000037624 Vega:OTTMUSG00000051040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TREK-1; AI848635; A430027H14Rik
    Expression
    Broad expression in CNS E18 (RPKM 6.7), cortex adult (RPKM 5.7) and 19 other tissues See more
    Orthologs

    Genomic context

    See Kcnk2 in Genome Data Viewer
    Location:
    1; 1 H6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (189207930..189402704, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (191031809..191168071, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36561 Neighboring gene N-acetylneuraminic acid phosphatase pseudogene Neighboring gene programmed cell death 5, pseudogene Neighboring gene predicted gene, 46177 Neighboring gene predicted gene, 30088

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    outward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium ion leak channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stabilization of membrane potential TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    calyx of Held ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium channel subfamily K member 2
    Names
    TREK-1 K(+) channel subunit
    outward rectifying potassium channel protein TREK-1
    two pore potassium channel TPKC1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159850.1NP_001153322.1  potassium channel subfamily K member 2 isoform 1

      See identical proteins and their annotated locations for NP_001153322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK140716, BC062094, BY252821, BY276415, BY276551
      Consensus CDS
      CCDS48480.1
      UniProtKB/Swiss-Prot
      P97438
      UniProtKB/TrEMBL
      Q6P6P9
      Related
      ENSMUSP00000141891.1, OTTMUSP00000069501, ENSMUST00000193319.5, OTTMUST00000129387
      Conserved Domains (1) summary
      pfam07885
      Location:139196
      Ion_trans_2; Ion channel
    2. NM_001281847.1NP_001268776.1  potassium channel subfamily K member 2 isoform 3

      See identical proteins and their annotated locations for NP_001268776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK140716, BC062094, BF472201
      Consensus CDS
      CCDS78773.1
      UniProtKB/TrEMBL
      Q6P6P9
      Related
      ENSMUSP00000078416.7, OTTMUSP00000069520, ENSMUST00000079451.12, OTTMUST00000129440
      Conserved Domains (1) summary
      pfam07885
      Location:127184
      Ion_trans_2; Ion channel
    3. NM_001281848.1NP_001268777.1  potassium channel subfamily K member 2 isoform 4

      See identical proteins and their annotated locations for NP_001268777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK164197, BQ174170
      Conserved Domains (1) summary
      pfam07885
      Location:137215
      Ion_trans_2; Ion channel
    4. NM_001357119.1NP_001344048.1  potassium channel subfamily K member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121882, AC124527
      Conserved Domains (1) summary
      pfam07885
      Location:137215
      Ion_trans_2; Ion channel
    5. NM_010607.3NP_034737.2  potassium channel subfamily K member 2 isoform 2

      See identical proteins and their annotated locations for NP_034737.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC124527, BE654630, BM945997, BQ174170, BQ572833, BY267214, CN528767, CX211547
      Consensus CDS
      CCDS48481.1
      UniProtKB/Swiss-Prot
      P97438
      Related
      ENSMUSP00000141849.1, OTTMUSP00000069523, ENSMUST00000192723.1, OTTMUST00000129443
      Conserved Domains (1) summary
      pfam07885
      Location:124181
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      189207930..189402704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497121.3XP_006497184.1  potassium channel subfamily K member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YXK1
      Related
      ENSMUSP00000142026.1, OTTMUSP00000069522, ENSMUST00000194402.5, OTTMUST00000129442
      Conserved Domains (1) summary
      pfam07885
      Location:135192
      Ion_trans_2; Ion channel
    2. XM_006497122.3XP_006497185.1  potassium channel subfamily K member 2 isoform X2

      See identical proteins and their annotated locations for XP_006497185.1

      Conserved Domains (1) summary
      pfam07885
      Location:137215
      Ion_trans_2; Ion channel
    3. XM_017318154.1XP_017173643.1  potassium channel subfamily K member 2 isoform X2

      Conserved Domains (1) summary
      pfam07885
      Location:137215
      Ion_trans_2; Ion channel
    Support Center