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    Agfg1 ArfGAP with FG repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 15463, updated on 5-Aug-2018

    Summary

    Official Symbol
    Agfg1provided by MGI
    Official Full Name
    ArfGAP with FG repeats 1provided by MGI
    Primary source
    MGI:MGI:1333754
    See related
    Ensembl:ENSMUSG00000026159 Vega:OTTMUSG00000047960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrb; RAB; Rip; C85612; AU045498; C130049H11Rik; D730048C23Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 19.1), liver E14.5 (RPKM 13.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Agfg1 in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (82839460..82901001)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (82836058..82892850)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34450 Neighboring gene predicted gene, 46096 Neighboring gene potassium channel tetramerisation domain containing 3 pseudogene Neighboring gene solute carrier family 19, member 3 Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid nucleus differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    arf-GAP domain and FG repeat-containing protein 1
    Names
    HIV-1 Rev binding protein
    HIV-1 Rev-binding protein homolog
    arf-GAP domain and FG repeats-containing protein 1
    nucleoporin-like protein RIP

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310713.1NP_001297642.1  arf-GAP domain and FG repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC125444, AK048326, AK049400, CJ159641
      Consensus CDS
      CCDS78634.1
      UniProtKB/Swiss-Prot
      Q8K2K6
      Related
      ENSMUSP00000109071.2, OTTMUSP00000067373, ENSMUST00000113444.7, OTTMUST00000123310
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    2. NM_001347077.1NP_001334006.1  arf-GAP domain and FG repeat-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125444, AC138214
      Consensus CDS
      CCDS83564.1
      UniProtKB/TrEMBL
      A0A087WSR7
    3. NM_010472.3NP_034602.1  arf-GAP domain and FG repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_034602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC125444, AK048326, CJ159641
      Consensus CDS
      CCDS15100.1
      UniProtKB/Swiss-Prot
      Q8K2K6
      Related
      ENSMUSP00000140170.1, OTTMUSP00000067372, ENSMUST00000189220.6, OTTMUST00000123309
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      82839460..82901001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496430.3XP_006496493.1  arf-GAP domain and FG repeat-containing protein 1 isoform X1

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    2. XM_006496432.3XP_006496495.1  arf-GAP domain and FG repeat-containing protein 1 isoform X3

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    3. XM_006496433.3XP_006496496.1  arf-GAP domain and FG repeat-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006496496.1

      UniProtKB/Swiss-Prot
      Q8K2K6
      Related
      ENSMUSP00000140785.1, OTTMUSP00000067377, ENSMUST00000186302.6, OTTMUST00000123314
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    4. XM_006496439.3XP_006496502.1  arf-GAP domain and FG repeat-containing protein 1 isoform X10

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    5. XM_006496431.3XP_006496494.1  arf-GAP domain and FG repeat-containing protein 1 isoform X2

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    6. XM_006496434.3XP_006496497.1  arf-GAP domain and FG repeat-containing protein 1 isoform X5

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    7. XM_006496435.3XP_006496498.1  arf-GAP domain and FG repeat-containing protein 1 isoform X6

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    8. XM_006496438.3XP_006496501.1  arf-GAP domain and FG repeat-containing protein 1 isoform X9

      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    9. XM_017316914.1XP_017172403.1  arf-GAP domain and FG repeat-containing protein 1 isoform X8

    10. XM_006496440.3XP_006496503.1  arf-GAP domain and FG repeat-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A087WNV1
      Related
      ENSMUSP00000139503.1, OTTMUSP00000067376, ENSMUST00000187899.6, OTTMUST00000123313
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    11. XM_006496436.3XP_006496499.1  arf-GAP domain and FG repeat-containing protein 1 isoform X7

      Related
      ENSMUSP00000141157.1, OTTMUSP00000067374, ENSMUST00000190052.6, OTTMUST00000123311
      Conserved Domains (1) summary
      smart00105
      Location:14135
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

    RNA

    1. XR_001781825.1 RNA Sequence

    2. XR_001781822.1 RNA Sequence

    3. XR_373537.3 RNA Sequence

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