Format

Send to:

Choose Destination
    • Showing Current items.

    Fmo1 flavin containing monooxygenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14261, updated on 7-Aug-2018

    Summary

    Official Symbol
    Fmo1provided by MGI
    Official Full Name
    flavin containing monooxygenase 1provided by MGI
    Primary source
    MGI:MGI:1310002
    See related
    Ensembl:ENSMUSG00000040181 Vega:OTTMUSG00000024069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in kidney adult (RPKM 131.1), placenta adult (RPKM 107.8) and 9 other tissues See more
    Orthologs

    Genomic context

    See Fmo1 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (162829561..162866548, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (164759692..164796679, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2C Neighboring gene flavin containing monooxygenase 4 Neighboring gene predicted gene, 32197 Neighboring gene flavin containing monooxygenase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N,N-dimethylaniline monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    drug metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 1
    Names
    dimethylaniline oxidase 1
    hepatic flavin-containing monooxygenase 1
    NP_034361.1
    XP_006496725.1
    XP_006496726.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330291.1NP_001317220.1  dimethylaniline monooxygenase [N-oxide-forming] 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC117767, AC118643, AK143940, BU755220, D16215
      Consensus CDS
      CCDS15424.1
      UniProtKB/Swiss-Prot
      P50285
      UniProtKB/TrEMBL
      Q3UNX7
    2. NM_001330318.1NP_001317247.1  dimethylaniline monooxygenase [N-oxide-forming] 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 3' exons, and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117767, AC118643, AK042457
      UniProtKB/TrEMBL
      Q8C9C1
    3. NM_010231.3NP_034361.1  dimethylaniline monooxygenase [N-oxide-forming] 1 isoform 1

      See identical proteins and their annotated locations for NP_034361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC117767, AC118643, BU755220, D16215
      Consensus CDS
      CCDS15424.1
      UniProtKB/Swiss-Prot
      P50285
      Related
      ENSMUSP00000037259.7, OTTMUSP00000028565, ENSMUST00000046049.13, OTTMUST00000058842
      Conserved Domains (2) summary
      pfam00743
      Location:3532
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:7148
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      162829561..162866548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496662.3XP_006496725.1  dimethylaniline monooxygenase [N-oxide-forming] 1 isoform X1

      Conserved Domains (2) summary
      pfam00743
      Location:3532
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:7148
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006496663.3XP_006496726.1  dimethylaniline monooxygenase [N-oxide-forming] 1 isoform X1

      See identical proteins and their annotated locations for XP_006496726.1

      UniProtKB/Swiss-Prot
      P50285
      Conserved Domains (2) summary
      pfam00743
      Location:3532
      FMO-like; Flavin-binding monooxygenase-like
      cl21454
      Location:7148
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Support Center