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    Ackr1 atypical chemokine receptor 1 (Duffy blood group) [ Mus musculus (house mouse) ]

    Gene ID: 13349, updated on 18-Sep-2018

    Summary

    Official Symbol
    Ackr1provided by MGI
    Official Full Name
    atypical chemokine receptor 1 (Duffy blood group)provided by MGI
    Primary source
    MGI:MGI:1097689
    See related
    Ensembl:ENSMUSG00000037872 Vega:OTTMUSG00000050197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FY; Dfy; GPD; Darc; CCBP1; CD234; ESTM35; AA162249
    Expression
    Broad expression in cerebellum adult (RPKM 65.4), liver E14.5 (RPKM 38.7) and 18 other tissues See more
    Orthologs

    Genomic context

    See Ackr1 in Genome Data Viewer
    Location:
    1 H3; 1 80.33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (173331886..173333503, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (175262017..175263634, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 418 Neighboring gene mucosal pentraxin 2 Neighboring gene cell adhesion molecule 3 Neighboring gene absent in melanoma 2 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Non-odorant GPCRs, organism-specific biosystem (from WikiPathways)
      Non-odorant GPCRs, organism-specific biosystemListing of non-odorant Mouse GCPRs by coupling.

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chemokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 1
    Names
    Duffy antigen receptor for chemokines
    Duffy blood group, chemokine receptor
    duffy antigen/chemokine receptor
    glycoprotein D

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010045.2NP_034175.2  atypical chemokine receptor 1

      See identical proteins and their annotated locations for NP_034175.2

      Status: VALIDATED

      Source sequence(s)
      AC087781
      Consensus CDS
      CCDS35789.1
      UniProtKB/Swiss-Prot
      Q9QUI6
      UniProtKB/TrEMBL
      A0A0R4J0J4
      Related
      ENSMUSP00000045134.4, OTTMUSP00000068791, ENSMUST00000038227.5, OTTMUST00000127569
      Conserved Domains (1) summary
      cd15010
      Location:58314
      7tmA_ACKR1_DARC; Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      173331886..173333503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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