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    Cxcr4 chemokine (C-X-C motif) receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 12767, updated on 8-Dec-2018

    Summary

    Official Symbol
    Cxcr4provided by MGI
    Official Full Name
    chemokine (C-X-C motif) receptor 4provided by MGI
    Primary source
    MGI:MGI:109563
    See related
    Ensembl:ENSMUSG00000045382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1
    Expression
    Biased expression in thymus adult (RPKM 230.6), spleen adult (RPKM 93.9) and 10 other tissues See more
    Orthologs

    Genomic context

    See Cxcr4 in Genome Data Viewer
    Location:
    1 E3; 1 56.43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (128588199..128592311, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (130484776..130488876, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 41950 Neighboring gene thrombospondin, type I, domain containing 7B Neighboring gene predicted gene, 36347 Neighboring gene nucleoporin 54 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    C-X-C motif chemokine 12 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine binding IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CXCL12-activated CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    generation of neurons IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    neural precursor cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    telencephalon cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 4
    Names
    SDF-1 receptor
    chemokine (C-X-C) receptor 4
    chemokine receptor 4
    fusin
    leukocyte-derived seven transmembrane domain receptor
    leukocyte-expressed seven-transmembrane-domain
    pre-B-cell-derived chemokine receptor
    stromal cell-derived factor 1 receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356509.1NP_001343438.1  C-X-C chemokine receptor type 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161170
      Conserved Domains (2) summary
      pfam12109
      Location:638
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      cd15179
      Location:39318
      7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_009911.3NP_034041.2  C-X-C chemokine receptor type 4 isoform 1

      See identical proteins and their annotated locations for NP_034041.2

      Status: VALIDATED

      Source sequence(s)
      AB000803, BB872868, BF662224
      Consensus CDS
      CCDS15254.1
      UniProtKB/Swiss-Prot
      P70658
      UniProtKB/TrEMBL
      A0A0R4J0N8
      Related
      ENSMUSP00000053489.6, ENSMUST00000052172.6
      Conserved Domains (2) summary
      pfam00001
      Location:57309
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam12109
      Location:840
      CXCR4_N; CXCR4 Chemokine receptor N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      128588199..128592311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529113.3XP_006529176.1  C-X-C chemokine receptor type 4 isoform X1

      Conserved Domains (2) summary
      pfam12109
      Location:638
      CXCR4_N; CXCR4 Chemokine receptor N terminal
      cd15179
      Location:39318
      7tmA_CXCR4; CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_006529114.2XP_006529177.1  C-X-C chemokine receptor type 4 isoform X2

      Conserved Domains (2) summary
      pfam00001
      Location:54306
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam12109
      Location:537
      CXCR4_N; CXCR4 Chemokine receptor N terminal
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