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    Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit [ Mus musculus (house mouse) ]

    Gene ID: 12290, updated on 2-Oct-2018

    Summary

    Official Symbol
    Cacna1eprovided by MGI
    Official Full Name
    calcium channel, voltage-dependent, R type, alpha 1E subunitprovided by MGI
    Primary source
    MGI:MGI:106217
    See related
    Ensembl:ENSMUSG00000004110 Vega:OTTMUSG00000049818
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BII; Cach6; Cav2.3; Cchra1; alpha1E; Cacnl1a6; A430040I15
    Summary
    This gene encodes an integral membrane protein that belongs to the calcium channel alpha-1 subunits family. Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes. Voltage-dependent calcium channels are multi-subunit complexes, comprised of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The isoform alpha-1E gives rise to R-type calcium currents and belongs to the high-voltage activated group. Calcium channels containing the alpha-1E subunit may be involved in the modulation of neuronal firing patterns, an important component of information processing. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in frontal lobe adult (RPKM 6.4), cortex adult (RPKM 6.1) and 8 other tissues See more
    Orthologs

    Genomic context

    See Cacna1e in Genome Data Viewer
    Location:
    1 G3; 1 66.14 cM
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (154390806..154884786, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (156239649..156573050, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930532M18 gene Neighboring gene predicted gene, 30465 Neighboring gene golgi SNAP receptor complex member 1 pseudogene Neighboring gene predicted gene, 30521 Neighboring gene predicted gene, 41976 Neighboring gene predicted gene, 30602

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of somatostatin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated calcium channel complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    voltage-dependent R-type calcium channel subunit alpha-1E
    Names
    brain calcium channel II
    calcium channel, L type, alpha-1 polypeptide, isoform 6
    calcium channel, voltage-dependent, L type, alpha 1E subunit
    voltage-gated calcium channel subunit alpha Cav2.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009782.3NP_033912.2  voltage-dependent R-type calcium channel subunit alpha-1E

      Status: REVIEWED

      Source sequence(s)
      AC099707, AC101727, AC122040
      Consensus CDS
      CCDS78710.1
      UniProtKB/TrEMBL
      A0A087WS83
      Related
      ENSMUSP00000140937.1, OTTMUSP00000068577, ENSMUST00000187541.6, OTTMUST00000126873
      Conserved Domains (5) summary
      pfam00520
      Location:14981737
      Ion_trans; Ion transport protein
      pfam05439
      Location:341374
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:20132117
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:18101884
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:17451808
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      154390806..154884786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312578.1XP_017168067.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22062310
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    2. XM_017312848.1XP_017168337.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

      Conserved Domains (5) summary
      pfam00520
      Location:14981737
      Ion_trans; Ion transport protein
      pfam05439
      Location:341374
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:20602164
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:18101884
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:17451808
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    3. XM_017312712.1XP_017168201.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X8

      Conserved Domains (5) summary
      pfam00520
      Location:16141853
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21762280
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19262000
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18611924
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    4. XM_017312795.1XP_017168284.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X12

      Conserved Domains (5) summary
      pfam00520
      Location:16251864
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21402244
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19372011
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18721935
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    5. XM_017312682.1XP_017168171.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X7

      Conserved Domains (5) summary
      pfam00520
      Location:16251864
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21832287
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19372011
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18721935
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    6. XM_017312660.1XP_017168149.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X6

      Conserved Domains (5) summary
      pfam00520
      Location:16251864
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21872291
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19372011
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18721935
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    7. XM_017312824.1XP_017168313.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X13

      Conserved Domains (5) summary
      pfam00520
      Location:16251864
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21402244
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19372011
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18721935
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    8. XM_017312628.1XP_017168117.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X4

      Conserved Domains (5) summary
      pfam00520
      Location:16401879
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22022306
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19522026
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18871950
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    9. XM_017312642.1XP_017168131.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X5

      Conserved Domains (5) summary
      pfam00520
      Location:16401879
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22022306
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19522026
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18871950
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    10. XM_017312745.1XP_017168234.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X10

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21592263
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    11. XM_017312619.1XP_017168108.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X3

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22022306
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    12. XM_017312730.1XP_017168219.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X9

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:21632267
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    13. XM_017312766.1XP_017168255.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X11

    14. XM_017312613.1XP_017168102.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22062310
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    15. XM_017312594.1XP_017168083.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22062310
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    16. XM_011247909.2XP_011246211.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1

      See identical proteins and their annotated locations for XP_011246211.1

      Conserved Domains (5) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:22062310
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:19562030
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:18911954
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    17. XM_011247916.2XP_011246218.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X14

      Conserved Domains (5) summary
      pfam00520
      Location:14981737
      Ion_trans; Ion transport protein
      pfam05439
      Location:341374
      JTB; Jumping translocation breakpoint protein (JTB)
      pfam07816
      Location:20602164
      DUF1645; Protein of unknown function (DUF1645)
      pfam08763
      Location:18101884
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:17451808
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    18. XM_017312855.1XP_017168344.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X15

    19. XM_006529105.3XP_006529168.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X17

      Conserved Domains (2) summary
      pfam00520
      Location:16441883
      Ion_trans; Ion transport protein
      pfam05439
      Location:487520
      JTB; Jumping translocation breakpoint protein (JTB)
    20. XM_017312867.1XP_017168356.1  voltage-dependent R-type calcium channel subunit alpha-1E isoform X16

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