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H3f3a H3 histone, family 3A [ Mus musculus (house mouse) ]

Gene ID: 15078, updated on 30-Sep-2018

Summary

Official Symbol
H3f3aprovided by MGI
Official Full Name
H3 histone, family 3Aprovided by MGI
Primary source
MGI:MGI:1097686
See related
Ensembl:ENSMUSG00000060743 Vega:OTTMUSG00000021525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3.3A; EyeLinc14
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]
Expression
Broad expression in liver E14 (RPKM 493.6), CNS E14 (RPKM 457.6) and 26 other tissues See more
Orthologs

Genomic context

See H3f3a in Genome Data Viewer
Location:
1; 1 H4
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (180802560..180813605, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182732699..182743734, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38293 Neighboring gene RIKEN cDNA 2900024J01 gene Neighboring gene RIKEN cDNA G370120E05 gene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene SDE2 telomere maintenance homolog (S. pombe)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102150

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosomal DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of chromosome condensation IGI
Inferred from Genetic Interaction
more info
PubMed 
nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
pericentric heterochromatin assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
single fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomeric heterochromatin assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
Barr body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear nucleosome ISO
Inferred from Sequence Orthology
more info
 
nucleosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008210.5NP_032236.1  histone H3.3

    See identical proteins and their annotated locations for NP_032236.1

    Status: REVIEWED

    Source sequence(s)
    AC121292
    Consensus CDS
    CCDS15573.1
    UniProtKB/Swiss-Prot
    P84244
    Related
    ENSMUSP00000124509.1, OTTMUSP00000023970, ENSMUST00000161308.7, OTTMUST00000051055
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    180802560..180813605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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