Format

Send to:

Choose Destination
    • Showing Current items.

    Glul glutamate-ammonia ligase (glutamine synthetase) [ Mus musculus (house mouse) ]

    Gene ID: 14645, updated on 9-Oct-2018

    Summary

    Official Symbol
    Glulprovided by MGI
    Official Full Name
    glutamate-ammonia ligase (glutamine synthetase)provided by MGI
    Primary source
    MGI:MGI:95739
    See related
    Ensembl:ENSMUSG00000026473 Vega:OTTMUSG00000016462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GS; Glns
    Expression
    Broad expression in genital fat pad adult (RPKM 555.7), frontal lobe adult (RPKM 388.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See Glul in Genome Data Viewer
    Location:
    1; 1 G3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (153899929..153909723)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (155747075..155756844)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene transmembrane epididymal protein 1A Neighboring gene predicted gene, 38440 Neighboring gene microRNA 8114 Neighboring gene uncharacterized LOC108167736 Neighboring gene predicted gene, 30327 Neighboring gene predicted gene, 46165

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    dynein light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate-ammonia ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ammonia assimilation cycle ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glutamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    nitrogen compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamine synthetase
    Names
    glutamate decarboxylase
    glutamate-ammonia ligase (glutamine synthase)
    NP_032157.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008131.4NP_032157.2  glutamine synthetase

      See identical proteins and their annotated locations for NP_032157.2

      Status: VALIDATED

      Source sequence(s)
      AC099702, AK159106, BE946110
      Consensus CDS
      CCDS15381.1
      UniProtKB/Swiss-Prot
      P15105
      Related
      ENSMUSP00000083375.5, OTTMUSP00000017702, ENSMUST00000086199.11, OTTMUST00000039662
      Conserved Domains (3) summary
      PLN02284
      Location:22362
      PLN02284; glutamine synthetase
      pfam00120
      Location:114356
      Gln-synt_C; Glutamine synthetase, catalytic domain
      pfam03951
      Location:30104
      Gln-synt_N; Glutamine synthetase, beta-Grasp domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      153899929..153909723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center