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    Epha4 Eph receptor A4 [ Mus musculus (house mouse) ]

    Gene ID: 13838, updated on 8-Jul-2018
    Official Symbol
    Epha4provided by MGI
    Official Full Name
    Eph receptor A4provided by MGI
    Primary source
    MGI:MGI:98277
    See related
    Ensembl:ENSMUSG00000026235 Vega:OTTMUSG00000047778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rb; Sek; Cek8; Hek8; Sek1; Tyro1; AI385584; 2900005C20Rik
    Expression
    Biased expression in cortex adult (RPKM 17.3), whole brain E14.5 (RPKM 14.7) and 13 other tissues See more
    Orthologs
    See Epha4 in Genome Data Viewer
    Location:
    1 C4; 1 39.55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (77367182..77515103, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (77363760..77511663, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene transcription factor Dp 1, pseudogene Neighboring gene microRNA 6352 Neighboring gene predicted gene, 32793 Neighboring gene predicted gene, 32974

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    GPI-linked ephrin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane-ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to amyloid-beta IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    corticospinal tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fasciculation of motor neuron axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fasciculation of sensory neuron axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axon extension IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nephric duct morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection fasciculation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of modification of synaptic structure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of modification of synaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ephrin type-A receptor 4
    Names
    tyrosine-protein kinase receptor MPK-3
    tyrosine-protein kinase receptor SEK-1
    NP_031962.2
    XP_006496470.1
    XP_006496471.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007936.3NP_031962.2  ephrin type-A receptor 4 precursor

      See identical proteins and their annotated locations for NP_031962.2

      Status: VALIDATED

      Source sequence(s)
      AC164875, AK147698, X65138
      Consensus CDS
      CCDS35627.1
      UniProtKB/Swiss-Prot
      Q03137
      Related
      ENSMUSP00000027451.6, ENSMUST00000027451.12
      Conserved Domains (7) summary
      cd09545
      Location:911981
      SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
      smart00454
      Location:915975
      SAM; Sterile alpha motif
      cd10482
      Location:30203
      EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
      cd00063
      Location:441532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:616882
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:621878
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:562616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      77367182..77515103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496407.2XP_006496470.1  ephrin type-A receptor 4 isoform X1

      Conserved Domains (6) summary
      cd10482
      Location:30203
      EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
      cd00063
      Location:441532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:616882
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:621878
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:562616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl15755
      Location:911949
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_006496408.1XP_006496471.1  ephrin type-A receptor 4 isoform X2

      Conserved Domains (7) summary
      cd09545
      Location:860930
      SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
      smart00454
      Location:864924
      SAM; Sterile alpha motif
      cd10473
      Location:3152
      EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
      cd00063
      Location:390481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:565831
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:570827
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:511565
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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