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    Cep170 centrosomal protein 170 [ Mus musculus (house mouse) ]

    Gene ID: 545389, updated on 3-Oct-2018

    Summary

    Official Symbol
    Cep170provided by MGI
    Official Full Name
    centrosomal protein 170provided by MGI
    Primary source
    MGI:MGI:1918348
    See related
    Ensembl:ENSMUSG00000057335 Vega:OTTMUSG00000050317
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI195353; 4933426L22Rik; A330004A13Rik
    Expression
    Broad expression in CNS E18 (RPKM 23.9), whole brain E14.5 (RPKM 21.2) and 17 other tissues See more
    Orthologs

    Genomic context

    See Cep170 in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (176729072..176814177, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (178663784..178737255, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36586 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene microRNA 350 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene 15423

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    centriolar subdistal appendage ISO
    Inferred from Sequence Orthology
    more info
     
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 170 kDa
    Names
    KARP-1-binding protein
    centrosomal protein 170kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099637.2NP_001093107.2  centrosomal protein of 170 kDa

      See identical proteins and their annotated locations for NP_001093107.2

      Status: VALIDATED

      Source sequence(s)
      AC113311, AC144905
      Consensus CDS
      CCDS48461.1
      UniProtKB/TrEMBL
      H7BX26
      Related
      ENSMUSP00000059562.6, ENSMUST00000057037.12
      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      176729072..176814177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321727.1XP_017177216.1  centrosomal protein of 170 kDa isoform X3

    2. XM_017321728.1XP_017177217.1  centrosomal protein of 170 kDa isoform X4

    3. XM_017321724.1XP_017177213.1  centrosomal protein of 170 kDa isoform X1

    4. XM_006496947.3XP_006497010.1  centrosomal protein of 170 kDa isoform X11

      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041372
      CEP170_C; CEP170 C-terminus
    5. XM_017321726.1XP_017177215.1  centrosomal protein of 170 kDa isoform X2

    6. XM_006496940.3XP_006497003.1  centrosomal protein of 170 kDa isoform X7

      See identical proteins and their annotated locations for XP_006497003.1

      UniProtKB/TrEMBL
      H7BX26
      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus
    7. XM_006496939.3XP_006497002.1  centrosomal protein of 170 kDa isoform X7

      See identical proteins and their annotated locations for XP_006497002.1

      UniProtKB/TrEMBL
      H7BX26
      Related
      ENSMUSP00000141769.1, OTTMUSP00000068868, ENSMUST00000195717.5, OTTMUST00000127758
      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021496
      CEP170_C; CEP170 C-terminus
    8. XM_017321736.1XP_017177225.1  centrosomal protein of 170 kDa isoform X13

    9. XM_006496945.3XP_006497008.1  centrosomal protein of 170 kDa isoform X10

      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041398
      CEP170_C; CEP170 C-terminus
    10. XM_017321729.1XP_017177218.1  centrosomal protein of 170 kDa isoform X5

    11. XM_017321725.1XP_017177214.1  centrosomal protein of 170 kDa isoform X1

    12. XM_006496937.3XP_006497000.1  centrosomal protein of 170 kDa isoform X6

      See identical proteins and their annotated locations for XP_006497000.1

      UniProtKB/Swiss-Prot
      Q6A065
      Related
      ENSMUSP00000141793.1, OTTMUSP00000068869, ENSMUST00000194727.5, OTTMUST00000127759
      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:8021506
      CEP170_C; CEP170 C-terminus
    13. XM_006496944.3XP_006497007.1  centrosomal protein of 170 kDa isoform X9

      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7041408
      CEP170_C; CEP170 C-terminus
    14. XM_006496943.3XP_006497006.1  centrosomal protein of 170 kDa isoform X8

      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:7521456
      CEP170_C; CEP170 C-terminus
    15. XM_006496948.3XP_006497011.1  centrosomal protein of 170 kDa isoform X12

      Conserved Domains (3) summary
      COG1716
      Location:12133
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:598
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:6541358
      CEP170_C; CEP170 C-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024722.1: Suppressed sequence

      Description
      NM_001024722.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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