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    Kif21b kinesin family member 21B [ Mus musculus (house mouse) ]

    Gene ID: 16565, updated on 9-Sep-2018

    Summary

    Official Symbol
    Kif21bprovided by MGI
    Official Full Name
    kinesin family member 21Bprovided by MGI
    Primary source
    MGI:MGI:109234
    See related
    Ensembl:ENSMUSG00000041642 Vega:OTTMUSG00000026867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0449; 2610511N21Rik
    Expression
    Broad expression in thymus adult (RPKM 74.1), whole brain E14.5 (RPKM 48.8) and 15 other tissues See more
    Orthologs

    Genomic context

    See Kif21b in Genome Data Viewer
    Location:
    1 E4; 1 59.61 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (136131401..136178014)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (138027978..138074591)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene predicted gene 15850 Neighboring gene maestro heat-like repeat family member 3 Neighboring gene innate immunity activator Neighboring gene predicted gene 3878

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA0449

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF21B
    Names
    N-5 kinesin
    kinesin-like protein KIF6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039472.2NP_001034561.1  kinesin-like protein KIF21B

      See identical proteins and their annotated locations for NP_001034561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC124550
      Consensus CDS
      CCDS15324.1
      UniProtKB/Swiss-Prot
      Q9QXL1
      UniProtKB/TrEMBL
      F8VQE2
      Related
      ENSMUSP00000074661.4, OTTMUSP00000052412, ENSMUST00000075164.10
      Conserved Domains (8) summary
      smart00129
      Location:9378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:13081617
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:13021615
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:661795
      PKK; Polo kinase kinase
      pfam16034
      Location:679807
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:13141348
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:9651101
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RNA

    1. NR_153829.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC124550

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      136131401..136178014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019962.2: Suppressed sequence

      Description
      NM_019962.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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