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    Dnm3 dynamin 3 [ Mus musculus (house mouse) ]

    Gene ID: 103967, updated on 12-Aug-2018

    Summary

    Official Symbol
    Dnm3provided by MGI
    Official Full Name
    dynamin 3provided by MGI
    Primary source
    MGI:MGI:1341299
    See related
    Ensembl:ENSMUSG00000040265 Vega:OTTMUSG00000029472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW061159; Dyna III; mKIAA0820; C530045C17; 9630020E24Rik; B230343F03Rik
    Expression
    Biased expression in cerebellum adult (RPKM 19.2), CNS E18 (RPKM 12.1) and 7 other tissues See more
    Orthologs

    Genomic context

    See Dnm3 in Genome Data Viewer
    Location:
    1; 1 H2.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (161982450..162478328, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (163917433..164408165, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene predicted gene, 31925 Neighboring gene RIKEN cDNA 2810442N19 gene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene microRNA 199a-2 Neighboring gene dynamin 3, opposite strand Neighboring gene microRNA 214 Neighboring gene predicted gene, 39688 Neighboring gene predicted gene, 31985 Neighboring gene predicted gene, 46247 Neighboring gene methyltransferase like 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 1 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 5 metabotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse structure or activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle budding from presynaptic endocytic zone membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    basal tubulobulbar complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine head IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendritic spine head ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynamin-3
    Names
    dynamin III
    t-dynamin
    testicular dynamin
    NP_001033708.1
    NP_766234.1
    XP_006496664.1
    XP_006496665.1
    XP_006496666.1
    XP_006496667.1
    XP_006496668.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038619.2NP_001033708.1  dynamin-3 isoform 1

      See identical proteins and their annotated locations for NP_001033708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK046124, AK049724, AK147678, AW047427
      UniProtKB/Swiss-Prot
      Q8BZ98
      Related
      ENSMUSP00000083241.5, OTTMUSP00000037853, ENSMUST00000086074.11
      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79738
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:651739
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:748831
      DUF4551; Protein of unknown function (DUF4551)
    2. NM_172646.3NP_766234.1  dynamin-3 isoform 2

      See identical proteins and their annotated locations for NP_766234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2).
      Source sequence(s)
      AK046124, AK049724, AK147678, AW047427
      Consensus CDS
      CCDS48417.1
      UniProtKB/Swiss-Prot
      Q8BZ98
      Related
      ENSMUSP00000064538.7, OTTMUSP00000037747, ENSMUST00000070330.13
      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79734
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:514625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:647735
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:744827
      DUF4551; Protein of unknown function (DUF4551)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      161982450..162478328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496604.3XP_006496667.1  dynamin-3 isoform X4

      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79748
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661749
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:758841
      DUF4551; Protein of unknown function (DUF4551)
    2. XM_006496602.3XP_006496665.1  dynamin-3 isoform X2

      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79744
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657745
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:754837
      DUF4551; Protein of unknown function (DUF4551)
    3. XM_006496601.3XP_006496664.1  dynamin-3 isoform X1

      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79748
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661749
      GED; Dynamin GTPase effector domain
      pfam15087
      Location:758841
      DUF4551; Protein of unknown function (DUF4551)
    4. XM_006496603.3XP_006496666.1  dynamin-3 isoform X3

      Conserved Domains (6) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79748
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      cd01256
      Location:526635
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661749
      GED; Dynamin GTPase effector domain
      pfam10630
      Location:771851
      DUF2476; Protein of unknown function (DUF2476)
    5. XM_006496605.3XP_006496668.1  dynamin-3 isoform X5

      Conserved Domains (3) summary
      smart00053
      Location:6245
      DYNc; Dynamin, GTPase
      COG0699
      Location:79500
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:217502
      Dynamin_M; Dynamin central region
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