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    Stx3 syntaxin 3 [ Mus musculus (house mouse) ]

    Gene ID: 20908, updated on 9-Sep-2018

    Summary

    Official Symbol
    Stx3provided by MGI
    Official Full Name
    syntaxin 3provided by MGI
    Primary source
    MGI:MGI:103077
    See related
    Ensembl:ENSMUSG00000041488 Vega:OTTMUSG00000061360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Syn-3
    Expression
    Broad expression in placenta adult (RPKM 14.0), cerebellum adult (RPKM 6.3) and 21 other tissues See more
    Orthologs

    Genomic context

    See Stx3 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (11775118..11819886, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (11849608..11893893, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene gastric intrinsic factor Neighboring gene predicted gene, 46655 Neighboring gene mitochondrial ribosomal protein L16 Neighboring gene olfactory receptor 1417 Neighboring gene olfactory receptor 1418

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    arachidonic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane fusion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle docking IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle-mediated transport in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    vesicle-mediated transport in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle-mediated transport in synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport in synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    Schaffer collateral - CA1 synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    photoreceptor cell terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribbon synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025307.2NP_001020478.1  syntaxin-3 isoform B

      See identical proteins and their annotated locations for NP_001020478.1

      Status: VALIDATED

      Source sequence(s)
      BC024844, BC056949, BM936677
      Consensus CDS
      CCDS29611.1
      UniProtKB/Swiss-Prot
      Q64704
      Related
      ENSMUSP00000074776.7, OTTMUSP00000077650, ENSMUST00000075304.13
      Conserved Domains (2) summary
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
      cl22856
      Location:194260
      SNARE; SNARE motif
    2. NM_001286543.2NP_001273472.1  syntaxin-3 isoform D

      See identical proteins and their annotated locations for NP_001273472.1

      Status: VALIDATED

      Source sequence(s)
      AC126266, BC024844, BC056949
      UniProtKB/Swiss-Prot
      Q64704
      Conserved Domains (2) summary
      cl22856
      Location:97163
      SNARE; SNARE motif
      cl26014
      Location:1129
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    3. NM_001360386.1NP_001347315.1  syntaxin-3 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC126036, AC126266
    4. NM_011502.4NP_035632.1  syntaxin-3 isoform C

      See identical proteins and their annotated locations for NP_035632.1

      Status: VALIDATED

      Source sequence(s)
      AC126266, BC024844, BC056949
      Consensus CDS
      CCDS29612.1
      UniProtKB/Swiss-Prot
      Q64704
      Related
      ENSMUSP00000147398.1, OTTMUSP00000077652, ENSMUST00000211641.1
      Conserved Domains (2) summary
      pfam00804
      Location:49208
      Syntaxin; Syntaxin
      cl22856
      Location:176242
      SNARE; SNARE motif
    5. NM_152220.2NP_689344.1  syntaxin-3 isoform A

      See identical proteins and their annotated locations for NP_689344.1

      Status: VALIDATED

      Source sequence(s)
      AC126266, AK133830, BC056949, BF318335, BG064925, BG079344, BX634318, CJ058200
      Consensus CDS
      CCDS29613.1
      UniProtKB/Swiss-Prot
      Q64704
      UniProtKB/TrEMBL
      Q3UZI9
      Related
      ENSMUSP00000069529.4, OTTMUSP00000077653, ENSMUST00000069285.5, OTTMUST00000149720
      Conserved Domains (2) summary
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
      cl22856
      Location:194260
      SNARE; SNARE motif

    RNA

    1. NR_153433.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126036, AC126266
    2. NR_153434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC126036, AC126266

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      11775118..11819886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318109.1XP_017173598.1  syntaxin-3 isoform X3

      Conserved Domains (2) summary
      cl22856
      Location:97163
      SNARE; SNARE motif
      cl26014
      Location:1129
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    2. XM_017318108.1XP_017173597.1  syntaxin-3 isoform X2

      Conserved Domains (2) summary
      cd00179
      Location:184
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15881
      Location:93160
      SNARE_syntaxin3; SNARE motif of syntaxin 3
    3. XM_006526845.3XP_006526908.1  syntaxin-3 isoform X2

      See identical proteins and their annotated locations for XP_006526908.1

      Conserved Domains (2) summary
      cd00179
      Location:184
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15881
      Location:93160
      SNARE_syntaxin3; SNARE motif of syntaxin 3
    4. XM_006526844.3XP_006526907.1  syntaxin-3 isoform X1

      Conserved Domains (3) summary
      cd00179
      Location:32181
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      pfam00804
      Location:32226
      Syntaxin; Syntaxin
      cl22856
      Location:190258
      SNARE; SNARE motif

    RNA

    1. XR_001782570.1 RNA Sequence

    2. XR_001782568.1 RNA Sequence

      Related
      ENSMUST00000047698.13, OTTMUST00000149718
    3. XR_001782567.1 RNA Sequence

    4. XR_001782569.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025308.1: Suppressed sequence

      Description
      NM_001025308.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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