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MS4A15 membrane spanning 4-domains A15 [ Homo sapiens (human) ]

Gene ID: 219995, updated on 29-Mar-2018
Official Symbol
MS4A15provided by HGNC
Official Full Name
membrane spanning 4-domains A15provided by HGNC
Primary source
HGNC:HGNC:28573
See related
Ensembl:ENSG00000166961 Vega:OTTHUMG00000167688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward lung (RPKM 22.2) See more
Orthologs
See MS4A15 in Genome Data Viewer
Location:
11q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (60756867..60776733)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60524340..60544204)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369321 Neighboring gene membrane spanning 4-domains A8 Neighboring gene membrane spanning 4-domains A18 Neighboring gene uncharacterized LOC105369322 Neighboring gene membrane spanning 4-domains A10 Neighboring gene coiled-coil domain containing 86 Neighboring gene prostaglandin D2 receptor 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Replication interactions

Interaction Pubs
Knockdown of membrane-spanning 4-domains, subfamily A, member 15 (MS4A15) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Homology

Clone Names

  • FLJ34527, MGC35295

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
membrane-spanning 4-domains subfamily A member 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098835.1NP_001092305.1  membrane-spanning 4-domains subfamily A member 15 isoform 1

    See identical proteins and their annotated locations for NP_001092305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AP004243, BC031610, BI818815, CR747020, DC359370
    Consensus CDS
    CCDS44617.1
    UniProtKB/Swiss-Prot
    Q8N5U1
    Related
    ENSP00000386022.3, OTTHUMP00000236475, ENST00000405633.3, OTTHUMT00000395618
    Conserved Domains (1) summary
    pfam04103
    Location:73195
    CD20; CD20-like family
  2. NM_001278242.1NP_001265171.1  membrane-spanning 4-domains subfamily A member 15 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK091846, AK300233, AY584609, DC359370
    Consensus CDS
    CCDS60802.1
    UniProtKB/Swiss-Prot
    Q8N5U1
    UniProtKB/TrEMBL
    B4DTI9
    Related
    ENSP00000434165.1, OTTHUMP00000236472, ENST00000528170.5, OTTHUMT00000395615
    Conserved Domains (1) summary
    pfam04103
    Location:60154
    CD20; CD20-like family
  3. NM_152717.2NP_689930.1  membrane-spanning 4-domains subfamily A member 15 isoform 2

    See identical proteins and their annotated locations for NP_689930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC031610, DC359370
    Consensus CDS
    CCDS7991.1
    UniProtKB/Swiss-Prot
    Q8N5U1
    Related
    ENSP00000338692.4, OTTHUMP00000236473, ENST00000337911.8, OTTHUMT00000395616
    Conserved Domains (1) summary
    pfam04103
    Location:15102
    CD20; CD20-like family

RNA

  1. NR_103481.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK091846, BC031610, DC359370
    Related
    ENST00000429322.6, OTTHUMT00000395617

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    60756867..60776733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544812.3XP_011543114.1  membrane-spanning 4-domains subfamily A member 15 isoform X1

    See identical proteins and their annotated locations for XP_011543114.1

    UniProtKB/Swiss-Prot
    Q8N5U1
    Conserved Domains (1) summary
    pfam04103
    Location:73195
    CD20; CD20-like family
  2. XM_006718459.4XP_006718522.1  membrane-spanning 4-domains subfamily A member 15 isoform X2

    See identical proteins and their annotated locations for XP_006718522.1

    UniProtKB/Swiss-Prot
    Q8N5U1
    Conserved Domains (1) summary
    pfam04103
    Location:15102
    CD20; CD20-like family
  3. XM_011544814.1XP_011543116.1  membrane-spanning 4-domains subfamily A member 15 isoform X2

    See identical proteins and their annotated locations for XP_011543116.1

    UniProtKB/Swiss-Prot
    Q8N5U1
    Conserved Domains (1) summary
    pfam04103
    Location:15102
    CD20; CD20-like family
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