Sign in to NCBI
Format

Send to:

Choose Destination
    • Showing Current items.

    Unc80 unc-80, NALCN activator [ Mus musculus (house mouse) ]

    Gene ID: 329178, updated on 27-Jan-2018

    Summary

    Go to the top of the page Help
    Official Symbol
    Unc80provided by MGI
    Official Full Name
    unc-80, NALCN activatorprovided by MGI
    Primary source
    MGI:MGI:2652882
    See related
    Ensembl:ENSMUSG00000055567 Vega:OTTMUSG00000026091
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UNC-80; C030018G13Rik; C230061B10Rik
    Expression
    Biased expression in cerebellum adult (RPKM 20.7), frontal lobe adult (RPKM 16.0) and 3 other tissues See more
    Orthologs
    human all

    Genomic context

    Go to the top of the page Help
    See Unc80 in Genome Data Viewer
    Location:
    1; 1 C3
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (66468296..66699148)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (66515021..66745722)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 8812 Neighboring gene microtubule-associated protein 2 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 39655 Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene predicted gene, 46093 Neighboring gene ribulose-5-phosphate-3-epimerase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Lu B, et al. Nature, 2009 Feb 5. PMID 19092807, Free PMC Article
    2. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Lu B, et al. Neuron, 2010 Nov 4. PMID 21040849, Free PMC Article
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    1. Therefore, extracellular Ca(2+) influences neuronal excitability through the unc-79 homolog modifier of locomotor activity 3-UNC80-NALCN complex in a G protein-dependent fashion
      Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
    2. in the mouse hippocampal and ventral tegmental area neurons, substance P and neurotensin activate a channel complex containing NALCN and a large previously unknown protein UNC-80
      Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Genotypes

    Pathways from BioSystems

    Go to the top of the page Help

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • AC118589.3

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein unc-80 homolog
    Names
    NALCN channel associated protein
    mUNC-80
    unc-80 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175510.3 → NP_780719.2  protein unc-80 homolog

      See identical proteins and their annotated locations for NP_780719.2

      Status: VALIDATED

      Source sequence(s)
      AC118589, AK081235, CX734185, FJ210934
      Consensus CDS
      CCDS48283.1
      UniProtKB/Swiss-Prot
      Q8BLN6
      UniProtKB/TrEMBL
      B8XCJ6
      Related
      ENSMUSP00000053692.9, OTTMUSP00000058076, ENSMUST00000061620.16, OTTMUST00000103888
      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      66468296..66699148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238547.2 → XP_011236849.1  protein unc-80 homolog isoform X16

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    2. XM_017321274.1 → XP_017176763.1  protein unc-80 homolog isoform X17

    3. XM_017321275.1 → XP_017176764.1  protein unc-80 homolog isoform X18

    4. XM_011238540.1 → XP_011236842.1  protein unc-80 homolog isoform X1

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    5. XM_011238544.1 → XP_011236846.1  protein unc-80 homolog isoform X6

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    6. XM_011238545.1 → XP_011236847.1  protein unc-80 homolog isoform X7

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    7. XM_011238541.1 → XP_011236843.1  protein unc-80 homolog isoform X2

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    8. XM_017321267.1 → XP_017176756.1  protein unc-80 homolog isoform X9

    9. XM_011238546.1 → XP_011236848.1  protein unc-80 homolog isoform X8

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    10. XM_017321270.1 → XP_017176759.1  protein unc-80 homolog isoform X10

    11. XM_006496086.2 → XP_006496149.1  protein unc-80 homolog isoform X5

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    12. XM_006496092.2 → XP_006496155.1  protein unc-80 homolog isoform X11

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    13. XM_017321271.1 → XP_017176760.1  protein unc-80 homolog isoform X12

    14. XM_017321273.1 → XP_017176762.1  protein unc-80 homolog isoform X14

    15. XM_011238542.1 → XP_011236844.1  protein unc-80 homolog isoform X3

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    16. XM_017321272.1 → XP_017176761.1  protein unc-80 homolog isoform X13

      Related
      ENSMUSP00000148517.1, OTTMUSP00000078040, ENSMUST00000212557.2, OTTMUST00000150531

    17. XM_011238543.1 → XP_011236845.1  protein unc-80 homolog isoform X4

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    18. XM_006496093.2 → XP_006496156.1  protein unc-80 homolog isoform X15

      Conserved Domains (1) summary
      pfam15778
      Location:16 → 236
      UNC80; Cation channel complex component UNC80

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187020.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      885806..1107214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLN6.2 GenPept UniProtKB/Swiss-Prot:Q8BLN6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous
    You are here: NCBI > Genes & Expression > Gene
    Support Center