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    Fn1 fibronectin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14268, updated on 3-Oct-2018

    Summary

    Official Symbol
    Fn1provided by MGI
    Official Full Name
    fibronectin 1provided by MGI
    Primary source
    MGI:MGI:95566
    See related
    Ensembl:ENSMUSG00000026193 Vega:OTTMUSG00000048807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fn; Fn-1; E330027I09
    Expression
    Broad expression in placenta adult (RPKM 211.5), liver E18 (RPKM 196.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See Fn1 in Genome Data Viewer
    Location:
    1 C3; 1 36.05 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (71585473..71653234, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (71632097..71699745, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6947 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene apolipoprotein L 7d Neighboring gene PRP4 pre-mRNA processing factor 4 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117493

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix structural constituent HDA PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    mercury ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-independent cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-substrate junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mercury ion ISO
    Inferred from Sequence Orthology
    more info
     
    endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    interaction with other organism via secreted substance involved in symbiotic interaction ISO
    Inferred from Sequence Orthology
    more info
     
    interaction with symbiont ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor-beta secretion ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell migration involved in autonomic nervous system development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate-dependent cell migration, cell attachment to substrate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix HDA PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    fibrinogen complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276408.1NP_001263337.1  fibronectin isoform b precursor

      See identical proteins and their annotated locations for NP_001263337.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147249, AK147683, CJ098561, CJ099024, CN534124
      Consensus CDS
      CCDS78612.1
      UniProtKB/TrEMBL
      A0A087WR50, Q3UGY5, Q3UHR1
      Related
      ENSMUSP00000140471.1, OTTMUSP00000067838, ENSMUST00000188894.6, OTTMUST00000124852
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22932332
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    2. NM_001276409.1NP_001263338.1  fibronectin isoform c precursor

      See identical proteins and their annotated locations for NP_001263338.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147315, CJ098561
      Consensus CDS
      CCDS78611.1
      UniProtKB/TrEMBL
      Q3UHL6
      Related
      ENSMUSP00000140975.1, OTTMUSP00000067841, ENSMUST00000187938.6, OTTMUST00000124856
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22682307
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    3. NM_001276410.1NP_001263339.1  fibronectin isoform d precursor

      See identical proteins and their annotated locations for NP_001263339.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147315, AK171339, CJ098561, CK639246, CN532664, CN536551, CN692112
      Consensus CDS
      CCDS78609.1
      UniProtKB/TrEMBL
      A0A087WSN6, Q3TBB4, Q3UHL6
      Related
      ENSMUSP00000141123.1, OTTMUSP00000067844, ENSMUST00000186129.6, OTTMUST00000124859
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22032242
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    4. NM_001276411.1NP_001263340.1  fibronectin isoform e precursor

      See identical proteins and their annotated locations for NP_001263340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147663, BC138421, CJ098561
      Consensus CDS
      CCDS78608.1
      UniProtKB/TrEMBL
      B9EHT6
      Related
      ENSMUSP00000140816.1, OTTMUSP00000067842, ENSMUST00000190780.6, OTTMUST00000124857
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21782217
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    5. NM_001276412.1NP_001263341.1  fibronectin isoform f precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147315, AK147639, CJ098561
      Consensus CDS
      CCDS78610.1
      UniProtKB/TrEMBL
      A0A087WS56, Q3UH17, Q3UHL6
      Related
      ENSMUSP00000140907.1, OTTMUSP00000067839, ENSMUST00000188674.6, OTTMUST00000124854
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21732212
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19031983
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    6. NM_001276413.1NP_001263342.1  fibronectin isoform g precursor

      See identical proteins and their annotated locations for NP_001263342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
      Source sequence(s)
      AC124821, AK147701, AK171339, CJ098561
      Consensus CDS
      CCDS78607.1
      UniProtKB/TrEMBL
      B7ZNJ1, Q3TBB4
      Related
      ENSMUSP00000139702.1, OTTMUSP00000067840, ENSMUST00000189821.6, OTTMUST00000124855
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:20832122
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18131893
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:14501529
      fn3; Fibronectin type III domain
    7. NM_010233.2NP_034363.1  fibronectin isoform a precursor

      See identical proteins and their annotated locations for NP_034363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC124821, AK133868, CF166960, CF727068, CJ098561, CK637170, CK638401, CN460535, CN534124, CN538894, CN694596
      Consensus CDS
      CCDS15031.1
      UniProtKB/Swiss-Prot
      P11276
      UniProtKB/TrEMBL
      Q3UZF9
      Related
      ENSMUSP00000054499.6, OTTMUSP00000067843, ENSMUST00000055226.12, OTTMUST00000124858
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23842423
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15411620
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      71585473..71653234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315848.1XP_017171337.1  fibronectin isoform X6

    2. XM_017315837.1XP_017171326.1  fibronectin isoform X5

    3. XM_006495699.3XP_006495762.1  fibronectin isoform X3

      See identical proteins and their annotated locations for XP_006495762.1

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15411620
      fn3; Fibronectin type III domain
    4. XM_006495700.3XP_006495763.1  fibronectin isoform X4

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22642303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15411620
      fn3; Fibronectin type III domain
    5. XM_006495697.3XP_006495760.1  fibronectin isoform X1

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:187231
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23592398
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19942074
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:232271
      fn1; Fibronectin type I domain
      pfam00041
      Location:15411620
      fn3; Fibronectin type III domain
    6. XM_017315775.1XP_017171264.1  fibronectin isoform X2

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