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    Spock2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2 [ Mus musculus (house mouse) ]

    Gene ID: 94214, updated on 12-Aug-2018

    Summary

    Official Symbol
    Spock2provided by MGI
    Official Full Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2provided by MGI
    Primary source
    MGI:MGI:1891351
    See related
    Ensembl:ENSMUSG00000058297 Vega:OTTMUSG00000029785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcap26; AA407235; mKIAA0275
    Expression
    Biased expression in cerebellum adult (RPKM 116.0), cortex adult (RPKM 84.9) and 12 other tissues See more
    Orthologs

    Genomic context

    See Spock2 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (60106257..60135198)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (59569005..59596662)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene DNA-damage-inducible transcript 4 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene microRNA 6906 Neighboring gene carbohydrate (chondroitin 6/keratan) sulfotransferase 3 Neighboring gene headcase homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    testican-2
    Names
    granule cell antiserum positive 26

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052994.2NP_443720.1  testican-2 precursor

      See identical proteins and their annotated locations for NP_443720.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057324
      Consensus CDS
      CCDS35910.1
      UniProtKB/Swiss-Prot
      Q9ER58
      Related
      ENSMUSP00000113115.2, OTTMUSP00000038323, ENSMUST00000121820.8, OTTMUST00000073921
      Conserved Domains (4) summary
      smart00280
      Location:147180
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:311375
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:198315
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:197302
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      60106257..60135198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314167.1XP_017169656.1  testican-2 isoform X2

    2. XM_006514347.3XP_006514410.1  testican-2 isoform X1

      Conserved Domains (4) summary
      smart00280
      Location:97130
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:261325
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:148265
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:147252
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
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