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    Cflar CASP8 and FADD-like apoptosis regulator [ Mus musculus (house mouse) ]

    Gene ID: 12633, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cflarprovided by MGI
    Official Full Name
    CASP8 and FADD-like apoptosis regulatorprovided by MGI
    Primary source
    MGI:MGI:1336166
    See related
    Ensembl:ENSMUSG00000026031 Vega:OTTMUSG00000019581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cash; Flip; MRIT; CLARP; FLAME; Casper; Gm9845; c-Flip; FLAME-1; I-FLICE; 2310024N18Rik; A430105C05Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 9.2), kidney adult (RPKM 7.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cflar in Genome Data Viewer
    Location:
    1 C1.3; 1 29.16 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (58711307..58759209)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (58770130..58815728)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene caspase 8 pseudogene Neighboring gene amyotrophic lateral sclerosis 2 chromosome region 12 Neighboring gene predicted gene, 39646 Neighboring gene caspase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103395

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    death receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CD95 death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    ripoptosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    FADD-like antiapoptotic molecule 1
    MACH-related inducer of toxicity
    caspase homolog
    caspase-eight-related protein
    caspase-like apoptosis regulatory protein
    cellular FLICE-like inhibitory protein
    inhibitor of FLICE
    usurpin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289704.3NP_001276633.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001276633.1

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Consensus CDS
      CCDS14978.1
      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Related
      ENSMUSP00000109952.1, OTTMUSP00000021142, ENSMUST00000114313.7
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. NM_001293804.2NP_001280733.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001280733.1

      Status: VALIDATED

      Source sequence(s)
      AC112968, AK152515
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    3. NM_001293805.2NP_001280734.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001280734.1

      Status: VALIDATED

      Source sequence(s)
      AC112968, AK161120
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    4. NM_001355056.1NP_001341985.1  CASP8 and FADD-like apoptosis regulator isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    5. NM_009805.4NP_033935.2  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_033935.2

      Status: VALIDATED

      Source sequence(s)
      BB856464, BC085105
      Consensus CDS
      CCDS35582.1
      UniProtKB/TrEMBL
      Q5U4G3
      Related
      ENSMUSP00000109948.1, OTTMUSP00000021144, ENSMUST00000114309.7, OTTMUST00000046768
      Conserved Domains (2) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. NM_207653.6NP_997536.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_997536.1

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Consensus CDS
      CCDS14978.1
      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Related
      ENSMUSP00000065107.7, OTTMUSP00000021143, ENSMUST00000069333.7
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RNA

    1. NR_149255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968
    2. NR_149256.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968
    3. NR_149257.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968, BX524743
    4. NR_149258.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      58711307..58759209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238420.2XP_011236722.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236722.1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. XM_011238421.2XP_011236723.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236723.1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Related
      ENSMUSP00000095329.2, OTTMUSP00000021141, ENSMUST00000097722.8, OTTMUST00000046765
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    3. XM_011238422.1XP_011236724.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236724.1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    4. XM_011238423.2XP_011236725.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236725.1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    5. XM_017313559.1XP_017169048.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. XM_006495635.3XP_006495698.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006495698.1

      UniProtKB/Swiss-Prot
      O35732
      UniProtKB/TrEMBL
      Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    7. XM_017313595.1XP_017169084.1  CASP8 and FADD-like apoptosis regulator isoform X2

      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
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