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    Elac1 elaC ribonuclease Z 1 [ Mus musculus (house mouse) ]

    Gene ID: 114615, updated on 12-Aug-2018

    Summary

    Official Symbol
    Elac1provided by MGI
    Official Full Name
    elaC ribonuclease Z 1provided by MGI
    Primary source
    MGI:MGI:1890495
    See related
    Ensembl:ENSMUSG00000036941 Vega:OTTMUSG00000029778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610018O07Rik; 8430417G19Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.6), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Elac1 in Genome Data Viewer
    Location:
    18; 18 E2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (73735038..73754841, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (73894692..73914133, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32548 Neighboring gene EGF-like domain 7 pseudogene Neighboring gene malic enzyme 2, NAD(+)-dependent, mitochondrial Neighboring gene predicted gene, 46631

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3'-tRNA processing endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    tRNA 3'-trailer cleavage IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc phosphodiesterase ELAC protein 1
    Names
    RNase Z 1
    elaC homolog 1
    elaC homolog protein 1
    ribonuclease Z 1
    tRNA 3 endonuclease 1
    tRNase Z 1
    NP_444485.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053255.3NP_444485.2  zinc phosphodiesterase ELAC protein 1

      See identical proteins and their annotated locations for NP_444485.2

      Status: VALIDATED

      Source sequence(s)
      AC132418, AF308697, AK018424, BY286576, CV556353
      Consensus CDS
      CCDS37855.1
      UniProtKB/Swiss-Prot
      Q8VEB6
      Related
      ENSMUSP00000041793.2, OTTMUSP00000038308, ENSMUST00000041138.2, OTTMUST00000073899
      Conserved Domains (2) summary
      COG1234
      Location:3359
      ElaC; Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]
      TIGR02651
      Location:4358
      RNase_Z; ribonuclease Z

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      73735038..73754841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_385970.3 RNA Sequence

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