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    Hnrnpu heterogeneous nuclear ribonucleoprotein U [ Mus musculus (house mouse) ]

    Gene ID: 51810, updated on 8-Jul-2018
    Official Symbol
    Hnrnpuprovided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Uprovided by MGI
    Primary source
    MGI:MGI:1858195
    See related
    Ensembl:ENSMUSG00000039630 Vega:OTTMUSG00000021881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAFA; Hnrpu; Sp120; C86794; hnRNP U; AA408410; AI256620; AL024194; AL024437; AW557595
    Expression
    Broad expression in CNS E11.5 (RPKM 88.9), CNS E14 (RPKM 47.2) and 25 other tissues See more
    Orthologs
    See Hnrnpu in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (178321108..178337810, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (180258431..180267915, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46174 Neighboring gene RIKEN cDNA B230369F24 gene Neighboring gene cytochrome c oxidase assembly protein 20 Neighboring gene EF-hand calcium binding domain 2 Neighboring gene predicted gene, 31289

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II C-terminal domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TFIIH-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(C) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
     
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    RNA localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leukemia inhibitory factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dosage compensation by inactivation of X chromosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    inactive sex chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inactive sex chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    heterogeneous nuclear ribonucleoprotein U
    Names
    heterogenous nuclear ribonucleoprotein U
    nuclear matrix protein sp120
    scaffold attachment factor A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016805.3NP_058085.2  heterogeneous nuclear ribonucleoprotein U

      See identical proteins and their annotated locations for NP_058085.2

      Status: VALIDATED

      Source sequence(s)
      AC166710, AK049600, AK145499, AW123430, BY766801, CX567350
      Consensus CDS
      CCDS35804.1
      UniProtKB/Swiss-Prot
      Q8VEK3
      Related
      ENSMUSP00000047571.7, OTTMUSP00000024527, ENSMUST00000037748.8
      Conserved Domains (5) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:475619
      AAA_33; AAA domain
      pfam15502
      Location:688778
      MPLKIP; M-phase-specific PLK1-interacting protein
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:475612
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RNA

    1. NR_149827.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA168064, AC166710, AK029944, AK040295, AK153188, BE650851, BY766801

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      178321108..178337810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321674.1XP_017177163.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/Swiss-Prot
      Q8VEK3
      Related
      ENSMUSP00000124147.1, OTTMUSP00000066763, ENSMUST00000161769.7, OTTMUST00000120749
      Conserved Domains (5) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:475619
      AAA_33; AAA domain
      pfam15502
      Location:688788
      MPLKIP; M-phase-specific PLK1-interacting protein
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:475612
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_017321673.1XP_017177162.1  heterogeneous nuclear ribonucleoprotein U isoform X2

      UniProtKB/Swiss-Prot
      Q8VEK3
      Conserved Domains (5) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:475619
      AAA_33; AAA domain
      pfam15502
      Location:688788
      MPLKIP; M-phase-specific PLK1-interacting protein
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:475612
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    3. XM_017321672.1XP_017177161.1  heterogeneous nuclear ribonucleoprotein U isoform X1

      UniProtKB/Swiss-Prot
      Q8VEK3
      Conserved Domains (5) summary
      smart00513
      Location:842
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:475619
      AAA_33; AAA domain
      pfam15502
      Location:688778
      MPLKIP; M-phase-specific PLK1-interacting protein
      cd12884
      Location:264439
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:475612
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
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