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    Ptbp1 polypyrimidine tract binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19205, updated on 17-Oct-2018

    Summary

    Official Symbol
    Ptbp1provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 1provided by MGI
    Primary source
    MGI:MGI:97791
    See related
    Ensembl:ENSMUSG00000006498 Vega:OTTMUSG00000035444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; AA407203; AL033359
    Expression
    Ubiquitous expression in thymus adult (RPKM 115.0), limb E14.5 (RPKM 113.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ptbp1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (79854432..79864435)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79317350..79327178)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene paralemmin Neighboring gene predicted gene, 40713 Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene phospholipid phosphatase related 3 Neighboring gene microRNA 6910 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of secretory granule organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polypyrimidine tract-binding protein 1
    Names
    heterogeneous nuclear ribonucleoprotein I
    hnRNP I

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077363.2NP_001070831.1  polypyrimidine tract-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001070831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK151292, CA977830, CJ075278
      Consensus CDS
      CCDS35969.1
      UniProtKB/TrEMBL
      Q922I7
      Related
      ENSMUSP00000126192.1, OTTMUSP00000049771, ENSMUST00000172282.7, OTTMUST00000090655
      Conserved Domains (1) summary
      TIGR01649
      Location:56555
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. NM_001283013.1NP_001269942.1  polypyrimidine tract-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001269942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate segment and an exon in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK036745, CA977830, CJ075278
      Consensus CDS
      CCDS70064.1
      UniProtKB/TrEMBL
      Q8CB58
      Related
      ENSMUSP00000093109.4, OTTMUSP00000049776, ENSMUST00000095457.10, OTTMUST00000090666
      Conserved Domains (3) summary
      cd12693
      Location:140235
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:36489
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:296388
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_008956.3NP_032982.2  polypyrimidine tract-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_032982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK082600, AK151292, CA977830, CJ075278
      Consensus CDS
      CCDS35970.1
      UniProtKB/TrEMBL
      Q8BGJ5, Q922I7
      Related
      ENSMUSP00000127783.1, OTTMUSP00000049772, ENSMUST00000165704.7, OTTMUST00000090658
      Conserved Domains (1) summary
      TIGR01649
      Location:56529
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      79854432..79864435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001779485.1 RNA Sequence

    2. XR_380379.1 RNA Sequence

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