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Cep170 centrosomal protein 170 [ Mus musculus (house mouse) ]

Gene ID: 545389, updated on 5-Aug-2018

Summary

Official Symbol
Cep170provided by MGI
Official Full Name
centrosomal protein 170provided by MGI
Primary source
MGI:MGI:1918348
See related
Ensembl:ENSMUSG00000057335 Vega:OTTMUSG00000050317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI195353; 4933426L22Rik; A330004A13Rik
Expression
Broad expression in CNS E18 (RPKM 23.9), whole brain E14.5 (RPKM 21.2) and 17 other tissues See more
Orthologs

Genomic context

See Cep170 in Genome Data Viewer
Location:
1; 1 H4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (176729072..176814177, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (178663784..178737255, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36586 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene microRNA 350 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene 15423

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centriole ISO
Inferred from Sequence Orthology
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centrosomal protein of 170 kDa
Names
KARP-1-binding protein
centrosomal protein 170kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099637.2NP_001093107.2  centrosomal protein of 170 kDa

    See identical proteins and their annotated locations for NP_001093107.2

    Status: VALIDATED

    Source sequence(s)
    AC113311, AC144905
    Consensus CDS
    CCDS48461.1
    UniProtKB/TrEMBL
    H7BX26
    Related
    ENSMUSP00000059562.6, ENSMUST00000057037.12
    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8021496
    CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    176729072..176814177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321727.1XP_017177216.1  centrosomal protein of 170 kDa isoform X3

  2. XM_017321728.1XP_017177217.1  centrosomal protein of 170 kDa isoform X4

  3. XM_017321724.1XP_017177213.1  centrosomal protein of 170 kDa isoform X1

  4. XM_006496947.3XP_006497010.1  centrosomal protein of 170 kDa isoform X11

    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7041372
    CEP170_C; CEP170 C-terminus
  5. XM_017321726.1XP_017177215.1  centrosomal protein of 170 kDa isoform X2

  6. XM_006496940.3XP_006497003.1  centrosomal protein of 170 kDa isoform X7

    See identical proteins and their annotated locations for XP_006497003.1

    UniProtKB/TrEMBL
    H7BX26
    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8021496
    CEP170_C; CEP170 C-terminus
  7. XM_006496939.3XP_006497002.1  centrosomal protein of 170 kDa isoform X7

    See identical proteins and their annotated locations for XP_006497002.1

    UniProtKB/TrEMBL
    H7BX26
    Related
    ENSMUSP00000141769.1, OTTMUSP00000068868, ENSMUST00000195717.5, OTTMUST00000127758
    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8021496
    CEP170_C; CEP170 C-terminus
  8. XM_017321736.1XP_017177225.1  centrosomal protein of 170 kDa isoform X13

  9. XM_006496945.3XP_006497008.1  centrosomal protein of 170 kDa isoform X10

    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7041398
    CEP170_C; CEP170 C-terminus
  10. XM_017321729.1XP_017177218.1  centrosomal protein of 170 kDa isoform X5

  11. XM_017321725.1XP_017177214.1  centrosomal protein of 170 kDa isoform X1

  12. XM_006496937.3XP_006497000.1  centrosomal protein of 170 kDa isoform X6

    See identical proteins and their annotated locations for XP_006497000.1

    UniProtKB/Swiss-Prot
    Q6A065
    Related
    ENSMUSP00000141793.1, OTTMUSP00000068869, ENSMUST00000194727.5, OTTMUST00000127759
    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:8021506
    CEP170_C; CEP170 C-terminus
  13. XM_006496944.3XP_006497007.1  centrosomal protein of 170 kDa isoform X9

    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7041408
    CEP170_C; CEP170 C-terminus
  14. XM_006496943.3XP_006497006.1  centrosomal protein of 170 kDa isoform X8

    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:7521456
    CEP170_C; CEP170 C-terminus
  15. XM_006496948.3XP_006497011.1  centrosomal protein of 170 kDa isoform X12

    Conserved Domains (3) summary
    COG1716
    Location:12133
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:598
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:6541358
    CEP170_C; CEP170 C-terminus

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024722.1: Suppressed sequence

    Description
    NM_001024722.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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