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    Dcun1d2 DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 102323, updated on 23-May-2018

    Summary

    Official Symbol
    Dcun1d2provided by MGI
    Official Full Name
    DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2142792
    See related
    Ensembl:ENSMUSG00000038506 Vega:OTTMUSG00000056854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW495713; mFLJ10704
    Expression
    Ubiquitous expression in heart adult (RPKM 17.4), cerebellum adult (RPKM 12.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dcun1d2 in Genome Data Viewer
    Location:
    8; 8 A1.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (13255963..13288126, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (13255963..13288126, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810030D12 gene Neighboring gene predicted gene, 34505 Neighboring gene ADP-ribosylhydrolase like 1 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene transcription factor Dp 1 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    DCN1-like protein 2
    Names
    DCUN1 domain-containing protein 2
    defective in cullin neddylation protein 1-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024504.2NP_001019675.2  DCN1-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_001019675.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
      Source sequence(s)
      AK155726, BU053156, BY232055, DV648583
      Consensus CDS
      CCDS40228.1
      UniProtKB/Swiss-Prot
      Q8BZJ7
      Related
      ENSMUSP00000047208.7, OTTMUSP00000073531, ENSMUST00000045366.9, OTTMUST00000140237
      Conserved Domains (2) summary
      pfam03556
      Location:137247
      Cullin_binding; Cullin binding
      cl21463
      Location:248
      UBA_like_SF; UBA domain-like superfamily
    2. NM_001042649.1NP_001036114.1  DCN1-like protein 2 isoform c

      See identical proteins and their annotated locations for NP_001036114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK155726, BU053156, BY232055, CD353600, DV648583
      Consensus CDS
      CCDS40230.1
      UniProtKB/Swiss-Prot
      Q8BZJ7
      UniProtKB/TrEMBL
      G5E8Q5
      Related
      ENSMUSP00000106462.1, OTTMUSP00000073532, ENSMUST00000110838.7, OTTMUST00000140238
      Conserved Domains (2) summary
      pfam03556
      Location:137173
      Cullin_binding; Cullin binding
      cl21463
      Location:248
      UBA_like_SF; UBA domain-like superfamily
    3. NM_001042650.1NP_001036115.1  DCN1-like protein 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the 3' coding region compared to variant 1. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AK155726, BU053156, BY232055, CA548310, DV648583
      Consensus CDS
      CCDS40227.1
      UniProtKB/Swiss-Prot
      Q8BZJ7
      Related
      ENSMUSP00000106464.1, OTTMUSP00000073529, ENSMUST00000110840.7, OTTMUST00000140235
      Conserved Domains (2) summary
      pfam03556
      Location:137187
      Cullin_binding; Cullin binding
      cl21463
      Location:248
      UBA_like_SF; UBA domain-like superfamily
    4. NM_001042651.1NP_001036116.1  DCN1-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001036116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK155726, AK161694, BU053156, BY232055, DV648583
      Consensus CDS
      CCDS40229.1
      UniProtKB/Swiss-Prot
      Q8BZJ7
      UniProtKB/TrEMBL
      G5E8Q6, Q3TSY8
      Related
      ENSMUSP00000106463.3, ENSMUST00000110839.9
      Conserved Domains (2) summary
      pfam03556
      Location:137203
      Cullin_binding; Cullin binding
      cl21463
      Location:248
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      13255963..13288126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508684.2XP_006508747.1  DCN1-like protein 2 isoform X1

      Conserved Domains (2) summary
      pfam03556
      Location:122232
      Cullin_binding; Cullin binding
      cl21463
      Location:133
      UBA_like_SF; UBA domain-like superfamily
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