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    H3f3a H3 histone, family 3A [ Mus musculus (house mouse) ]

    Gene ID: 15078, updated on 8-Dec-2018

    Summary

    Official Symbol
    H3f3aprovided by MGI
    Official Full Name
    H3 histone, family 3Aprovided by MGI
    Primary source
    MGI:MGI:1097686
    See related
    Ensembl:ENSMUSG00000060743
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H3.3A; EyeLinc14
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015]
    Expression
    Broad expression in liver E14 (RPKM 493.6), CNS E14 (RPKM 457.6) and 26 other tissues See more
    Orthologs

    Genomic context

    See H3f3a in Genome Data Viewer
    Location:
    1; 1 H4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (180802560..180813605, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182732699..182743734, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38293 Neighboring gene RIKEN cDNA 2900024J01 gene Neighboring gene RIKEN cDNA G370120E05 gene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene SDE2 telomere maintenance homolog (S. pombe)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102150

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleosomal DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of chromosome condensation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pericentric heterochromatin assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomeric heterochromatin assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Barr body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008210.5NP_032236.1  histone H3.3

      See identical proteins and their annotated locations for NP_032236.1

      Status: REVIEWED

      Source sequence(s)
      AC121292
      Consensus CDS
      CCDS15573.1
      UniProtKB/Swiss-Prot
      P84244
      Related
      ENSMUSP00000124509.1, ENSMUST00000161308.7
      Conserved Domains (1) summary
      PTZ00018
      Location:1136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      180802560..180813605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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