Format

Send to:

Choose Destination
    • Showing Current items.

    Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 347722, updated on 8-Jul-2018
    Official Symbol
    Agap1provided by MGI
    Official Full Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 1provided by MGI
    Primary source
    MGI:MGI:2653690
    See related
    Ensembl:ENSMUSG00000055013 Vega:OTTMUSG00000048341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ggap1; Centg2; R75364; mKIAA1099
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.5), cerebellum adult (RPKM 12.8) and 26 other tissues See more
    Orthologs
    See Agap1 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (89454811..89895282)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (91351386..91791857)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene RIKEN cDNA C030007H22 gene Neighboring gene predicted gene, 41913 Neighboring gene predicted gene 28499 Neighboring gene predicted gene, 41914 Neighboring gene RIKEN cDNA 4933400F21 gene Neighboring gene uncharacterized LOC102637806 Neighboring gene gastrulation brain homeobox 2 Neighboring gene predicted gene, 41915 Neighboring gene ankyrin repeat and SOCS box-containing 18

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Preferred Names
    arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    Names
    AGAP-1
    centaurin-gamma-2
    cnt-g2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037136.1NP_001032213.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC124227, AK046523, AK147503
      Consensus CDS
      CCDS15148.1
      UniProtKB/Swiss-Prot
      Q8BXK8
      UniProtKB/TrEMBL
      A0A087WRF2
      Related
      ENSMUSP00000140599.1, OTTMUSP00000067554, ENSMUST00000190096.6, OTTMUST00000123972
      Conserved Domains (8) summary
      cd04103
      Location:72229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00173
      Location:73235
      RAS; Ras subfamily of RAS small GTPases
      cd00204
      Location:683772
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:344539
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:347411
      PH; PH domain
      pfam01412
      Location:558672
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:683773
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:715746
      ANK; ANK repeat [structural motif]
    2. NM_178119.3NP_835220.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_835220.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC124227, AK046523, AK147503
      Consensus CDS
      CCDS15149.1
      UniProtKB/Swiss-Prot
      Q8BXK8
      Related
      ENSMUSP00000027521.8, OTTMUSP00000067553, ENSMUST00000027521.14, OTTMUST00000123971
      Conserved Domains (8) summary
      cd04103
      Location:72229
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00173
      Location:73235
      RAS; Ras subfamily of RAS small GTPases
      cd00204
      Location:736825
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:344592
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:347411
      PH; PH domain
      pfam01412
      Location:611725
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:736826
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:768799
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      89454811..89895282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center