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    Ppip5k2 diphosphoinositol pentakisphosphate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 227399, updated on 30-Jun-2018

    Summary

    Official Symbol
    Ppip5k2provided by MGI
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 2provided by MGI
    Primary source
    MGI:MGI:2142810
    See related
    Ensembl:ENSMUSG00000040648 Vega:OTTMUSG00000021900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vip2; Cfap160; Hisppd1; AW555814; mKIAA0433; D330021B20
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.9), CNS E14 (RPKM 10.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Ppip5k2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (97706043..97770406, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (99602623..99666669, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930009E08 gene Neighboring gene DNA segment, Chr 1, ERATO Doi 622, expressed Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    diphosphoinositol-pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diphosphoinositol-pentakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diphosphoinositol-pentakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inositol heptakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol hexakisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol hexakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    Names
    VIP1 homolog 2
    histidine acid phosphatase domain containing 1
    histidine acid phosphatase domain-containing protein 1
    insP6 and PP-IP5 kinase 2
    NP_776121.4
    XP_006529552.1
    XP_006529553.1
    XP_006529554.1
    XP_006529555.1
    XP_006529556.1
    XP_006529557.1
    XP_006529558.1
    XP_006529559.1
    XP_006529560.1
    XP_006529562.1
    XP_006529563.1
    XP_011246292.1
    XP_017175860.1
    XP_017175863.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173760.5NP_776121.4  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

      See identical proteins and their annotated locations for NP_776121.4

      Status: VALIDATED

      Source sequence(s)
      AC099860, AC162298, AK052286, AK087712, AK137392, AK138622, AK149804
      Consensus CDS
      CCDS35678.2
      UniProtKB/Swiss-Prot
      Q6ZQB6
      UniProtKB/TrEMBL
      Q8BWK5
      Related
      ENSMUSP00000043401.7, OTTMUSP00000024564, ENSMUST00000042509.12, OTTMUST00000052011
      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      97706043..97770406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529499.3XP_006529562.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    2. XM_006529489.1XP_006529552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006529552.1

      Related
      ENSMUSP00000108466.1, OTTMUSP00000024565, ENSMUST00000112845.7, OTTMUST00000052012
      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    3. XM_011247990.1XP_011246292.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

      Conserved Domains (2) summary
      COG0189
      Location:118300
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:342857
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    4. XM_006529500.2XP_006529563.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    5. XM_006529491.2XP_006529554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    6. XM_006529497.2XP_006529560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    7. XM_006529495.2XP_006529558.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    8. XM_017320374.1XP_017175863.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

    9. XM_006529496.2XP_006529559.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    10. XM_006529494.2XP_006529557.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    11. XM_017320371.1XP_017175860.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

    12. XM_006529493.2XP_006529556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    13. XM_006529492.2XP_006529555.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    14. XM_006529490.3XP_006529553.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006529553.1

      Conserved Domains (2) summary
      COG0189
      Location:54343
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
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