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Ppip5k2 diphosphoinositol pentakisphosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 227399, updated on 31-Jan-2019

Summary

Official Symbol
Ppip5k2provided by MGI
Official Full Name
diphosphoinositol pentakisphosphate kinase 2provided by MGI
Primary source
MGI:MGI:2142810
See related
Ensembl:ENSMUSG00000040648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vip2; Cfap160; Hisppd1; AW555814; mKIAA0433; D330021B20
Expression
Ubiquitous expression in CNS E18 (RPKM 10.9), CNS E14 (RPKM 10.8) and 26 other tissues See more
Orthologs

Genomic context

See Ppip5k2 in Genome Data Viewer
Location:
1; 1 D
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (97706043..97770406, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (99602623..99666669, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930009E08 gene Neighboring gene DNA segment, Chr 1, ERATO Doi 622, expressed Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
diphosphoinositol-pentakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diphosphoinositol-pentakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diphosphoinositol-pentakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
inositol heptakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol hexakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
 
inositol hexakisphosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
inositol hexakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol hexakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol hexakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
Names
VIP1 homolog 2
histidine acid phosphatase domain containing 1
histidine acid phosphatase domain-containing protein 1
insP6 and PP-IP5 kinase 2
NP_776121.4
XP_006529552.1
XP_006529553.1
XP_006529554.1
XP_006529555.1
XP_006529556.1
XP_006529557.1
XP_006529558.1
XP_006529559.1
XP_006529560.1
XP_006529562.1
XP_006529563.1
XP_011246292.1
XP_017175860.1
XP_017175863.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173760.5NP_776121.4  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

    See identical proteins and their annotated locations for NP_776121.4

    Status: VALIDATED

    Source sequence(s)
    AC099860, AC162298, AK052286, AK087712, AK137392, AK138622, AK149804
    Consensus CDS
    CCDS35678.2
    UniProtKB/Swiss-Prot
    Q6ZQB6
    UniProtKB/TrEMBL
    Q8BWK5
    Related
    ENSMUSP00000043401.7, ENSMUST00000042509.12
    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    97706043..97770406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529499.3XP_006529562.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385899
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  2. XM_006529489.1XP_006529552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006529552.1

    Related
    ENSMUSP00000108466.1, ENSMUST00000112845.7
    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  3. XM_011247990.1XP_011246292.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

    Conserved Domains (2) summary
    COG0189
    Location:118300
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:342857
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  4. XM_006529500.2XP_006529563.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

    Conserved Domains (1) summary
    pfam00328
    Location:140655
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  5. XM_006529491.2XP_006529554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385899
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  6. XM_006529497.2XP_006529560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  7. XM_006529495.2XP_006529558.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  8. XM_017320374.1XP_017175863.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

  9. XM_006529496.2XP_006529559.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  10. XM_006529494.2XP_006529557.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  11. XM_017320371.1XP_017175860.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

  12. XM_006529493.2XP_006529556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  13. XM_006529492.2XP_006529555.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
  14. XM_006529490.3XP_006529553.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006529553.1

    Conserved Domains (2) summary
    COG0189
    Location:54343
    RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
    pfam00328
    Location:385900
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
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