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    Mon2 MON2 homolog, regulator of endosome to Golgi trafficking [ Mus musculus (house mouse) ]

    Gene ID: 67074, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mon2provided by MGI
    Official Full Name
    MON2 homolog, regulator of endosome to Golgi traffickingprovided by MGI
    Primary source
    MGI:MGI:1914324
    See related
    Ensembl:ENSMUSG00000034602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf21; AW495628; mKIAA1040; 2610528O22Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.0), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mon2 in Genome Data Viewer
    Location:
    10; 10 D2
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (122992060..123076505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (122429117..122513561, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1H (PP2C domain containing) Neighboring gene predicted gene, 36208 Neighboring gene microRNA let7i Neighboring gene ubiquitin specific peptidase 15 Neighboring gene predicted gene, 36628

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163024.1NP_001156496.1  protein MON2 homolog isoform 1

      See identical proteins and their annotated locations for NP_001156496.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX122556, CX224591
      Consensus CDS
      CCDS48707.1
      UniProtKB/Swiss-Prot
      Q80TL7
      Related
      ENSMUSP00000073462.3, ENSMUST00000073792.10
      Conserved Domains (4) summary
      pfam09324
      Location:870929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9321706
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    2. NM_001163025.1NP_001156497.1  protein MON2 homolog isoform 2

      See identical proteins and their annotated locations for NP_001156497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN525456, CN528444, CN702930, CV561694, CV563363, CX224591
      Consensus CDS
      CCDS48708.1
      UniProtKB/TrEMBL
      B9EKJ3
      Related
      ENSMUSP00000131052.1, ENSMUST00000170935.8
      Conserved Domains (4) summary
      pfam09324
      Location:870929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9321700
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    3. NM_153395.2NP_700444.2  protein MON2 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX224591
      Consensus CDS
      CCDS24216.1
      UniProtKB/Swiss-Prot
      Q80TL7
      Related
      ENSMUSP00000037568.7, ENSMUST00000037557.8
      Conserved Domains (4) summary
      pfam09324
      Location:869928
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9311699
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      122992060..123076505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513970.3XP_006514033.1  protein MON2 homolog isoform X4

      Conserved Domains (4) summary
      pfam09324
      Location:871930
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9331701
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    2. XM_011243533.2XP_011241835.1  protein MON2 homolog isoform X1

      Conserved Domains (4) summary
      pfam09324
      Location:871930
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9331707
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    3. XM_006513968.3XP_006514031.1  protein MON2 homolog isoform X2

      Conserved Domains (4) summary
      pfam09324
      Location:870929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9321706
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    4. XM_006513969.3XP_006514032.1  protein MON2 homolog isoform X3

      Conserved Domains (4) summary
      pfam09324
      Location:869928
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:9311705
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9183
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    5. XM_017314065.1XP_017169554.1  protein MON2 homolog isoform X5

    6. XM_006513972.3XP_006514035.1  protein MON2 homolog isoform X6

      Conserved Domains (2) summary
      pfam09324
      Location:286345
      DUF1981; Domain of unknown function (DUF1981)
      pfam16206
      Location:3481122
      Mon2_C; C-terminal region of Mon2 protein

    RNA

    1. XR_380429.2 RNA Sequence

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