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    KGD4 alpha-ketoglutarate dehydrogenase subunit 4 [ Homo sapiens (human) ]

    Gene ID: 92259, updated on 17-Jun-2024

    Summary

    Official Symbol
    KGD4provided by HGNC
    Official Full Name
    alpha-ketoglutarate dehydrogenase subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:16631
    See related
    Ensembl:ENSG00000134056 MIM:611996; AllianceGenome:HGNC:16631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DC47; MRPS36; MRP-S36
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 19.9), heart (RPKM 18.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KGD4 in Genome Data Viewer
    Location:
    5q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69217760..69230158)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (70040372..70055914)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68513587..68525985)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267932 Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene centromere protein H Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22641 Neighboring gene Sharpr-MPRA regulatory region 69 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68515812-68516436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68530435-68530963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:68532675-68533175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68545886-68546386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68546387-68546887 Neighboring gene cyclin dependent kinase 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68561629-68562129 Neighboring gene coiled-coil domain containing 125 Neighboring gene cofilin 1 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC22896

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    alpha-ketoglutarate dehydrogenase component 4
    Names
    28S ribosomal protein S36, mitochondrial
    S36mt
    mitochondrial ribosomal protein S36

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033281.6NP_150597.1  alpha-ketoglutarate dehydrogenase component 4

      See identical proteins and their annotated locations for NP_150597.1

      Status: VALIDATED

      Source sequence(s)
      AC145132, BC015966
      Consensus CDS
      CCDS34174.1
      UniProtKB/Swiss-Prot
      P82909, Q9H2H4
      Related
      ENSP00000256441.4, ENST00000256441.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      69217760..69230158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315917.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      942..13338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      70040372..70055914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)