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    NMI N-myc and STAT interactor [ Homo sapiens (human) ]

    Gene ID: 9111, updated on 17-Jun-2024

    Summary

    Official Symbol
    NMIprovided by HGNC
    Official Full Name
    N-myc and STAT interactorprovided by HGNC
    Primary source
    HGNC:HGNC:7854
    See related
    Ensembl:ENSG00000123609 MIM:603525; AllianceGenome:HGNC:7854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 16.7), bone marrow (RPKM 15.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NMI in Genome Data Viewer
    Location:
    2q23.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (151270470..151289668, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (151722213..151741416, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152126984..152146182, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 5 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16629 Neighboring gene RNA binding motif protein 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16634 Neighboring gene uncharacterized LOC107985827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16635 Neighboring gene uncharacterized LOC101929319 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:152195619-152196139 Neighboring gene TNF alpha induced protein 6 Neighboring gene microRNA 4773-1 Neighboring gene microRNA 4773-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates N-myc (and STAT) interactor in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interferon-alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004688.3NP_004679.2  N-myc-interactor

      See identical proteins and their annotated locations for NP_004679.2

      Status: REVIEWED

      Source sequence(s)
      BC001268, BC021987, CB151555
      Consensus CDS
      CCDS2192.1
      UniProtKB/Swiss-Prot
      B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5
      UniProtKB/TrEMBL
      A8K683
      Related
      ENSP00000243346.5, ENST00000243346.10
      Conserved Domains (3) summary
      cd12544
      Location:157237
      RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
      pfam07292
      Location:203291
      NID; Nmi/IFP 35 domain (NID)
      pfam07334
      Location:29104
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      151270470..151289668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246941.3XP_005246998.1  N-myc-interactor isoform X2

      See identical proteins and their annotated locations for XP_005246998.1

      UniProtKB/Swiss-Prot
      B5BU69, Q13287, Q53TI8, Q8WTW2, Q9BVE5
      UniProtKB/TrEMBL
      A8K683
      Conserved Domains (3) summary
      cd12544
      Location:157237
      RRM_NMI; RNA recognition motif in N-myc-interactor (Nmi) and similar proteins
      pfam07292
      Location:203291
      NID; Nmi/IFP 35 domain (NID)
      pfam07334
      Location:29104
      IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    2. XM_047446270.1XP_047302226.1  N-myc-interactor isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      151722213..151741416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344474.1XP_054200449.1  N-myc-interactor isoform X2

      UniProtKB/TrEMBL
      A8K683
    2. XM_054344473.1XP_054200448.1  N-myc-interactor isoform X1