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    ENDOU endonuclease, poly(U) specific [ Homo sapiens (human) ]

    Gene ID: 8909, updated on 17-Jun-2019

    Summary

    Official Symbol
    ENDOUprovided by HGNC
    Official Full Name
    endonuclease, poly(U) specificprovided by HGNC
    Primary source
    HGNC:HGNC:14369
    See related
    Ensembl:ENSG00000111405 MIM:606720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P11; PP11; PRSS26
    Summary
    This gene encodes a protein with protease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010]
    Expression
    Biased expression in esophagus (RPKM 34.0), skin (RPKM 9.4) and 1 other tissue See more
    Orthologs

    Genomic context

    See ENDOU in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (47709734..47725490, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48103517..48119355, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene starch binding domain 1 pseudogene Neighboring gene RNA polymerase II associated protein 3 Neighboring gene Sharpr-MPRA regulatory region 11797 Neighboring gene uncharacterized LOC105369748 Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene solute carrier family 48 member 1 Neighboring gene histone deacetylase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133268

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    manganese ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis, endonucleolytic IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    poly(U)-specific endoribonuclease
    Names
    22 serine protease
    26 serine protease
    endonuclease, polyU-specific
    placental protein 11
    protein endoU
    uridylate-specific endoribonuclease
    NP_001165910.1
    NP_001165911.1
    NP_006016.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172439.2NP_001165910.1  poly(U)-specific endoribonuclease isoform 1 precursor

      See identical proteins and their annotated locations for NP_001165910.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AI039727, AK075446, BC069698
      Consensus CDS
      CCDS53785.1
      UniProtKB/Swiss-Prot
      P21128
      Related
      ENSP00000397679.3, ENST00000422538.8
      Conserved Domains (3) summary
      smart00201
      Location:86128
      SO; Somatomedin B -like domains
      pfam01033
      Location:2260
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:139405
      XendoU; Endoribonuclease XendoU
    2. NM_001172440.2NP_001165911.1  poly(U)-specific endoribonuclease isoform 3 precursor

      See identical proteins and their annotated locations for NP_001165911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame coding region segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC004241, AI039727, AK300169, DC381238
      Consensus CDS
      CCDS53784.1
      UniProtKB/Swiss-Prot
      P21128
      Related
      ENSP00000445004.2, ENST00000545824.2
      Conserved Domains (2) summary
      smart00201
      Location:2365
      SO; Somatomedin B -like domains
      pfam09412
      Location:76342
      XendoU; Endoribonuclease XendoU
    3. NM_006025.4NP_006016.1  poly(U)-specific endoribonuclease isoform 2 precursor

      See identical proteins and their annotated locations for NP_006016.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC004241, AI039727, BC111782
      Consensus CDS
      CCDS8754.1
      UniProtKB/Swiss-Prot
      P21128
      Related
      ENSP00000229003.3, ENST00000229003.7
      Conserved Domains (2) summary
      smart00201
      Location:4587
      SO; Somatomedin B -like domains
      pfam09412
      Location:98364
      XendoU; Endoribonuclease XendoU

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      47709734..47725490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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