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    FIP1L1 factor interacting with PAPOLA and CPSF1 [ Homo sapiens (human) ]

    Gene ID: 81608, updated on 19-Sep-2024

    Summary

    Official Symbol
    FIP1L1provided by HGNC
    Official Full Name
    factor interacting with PAPOLA and CPSF1provided by HGNC
    Primary source
    HGNC:HGNC:19124
    See related
    Ensembl:ENSG00000145216 MIM:607686; AllianceGenome:HGNC:19124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rhe; FIP1; hFip1
    Summary
    This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.3), brain (RPKM 11.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FIP1L1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (53377641..53460862)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56864883..56948080)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (54243808..54327029)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sec1 family domain containing 2 Neighboring gene uncharacterized LOC124900701 Neighboring gene VISTA enhancer hs1668 Neighboring gene VISTA enhancer hs1460 Neighboring gene NANOG hESC enhancer GRCh37_chr4:54102933-54103444 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:54103445-54103956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54122352-54122863 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:54140029-54140243 Neighboring gene RNA, U6 small nuclear 310, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:54195258-54195835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21561 Neighboring gene uncharacterized LOC105377654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54243526-54244074 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54244075-54244623 Neighboring gene LNX1 antisense RNA 1 Neighboring gene ligand of numb-protein X 1 Neighboring gene COMMD5 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
    EBI GWAS Catalog
    Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ33619, DKFZp586K0717

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    pre-mRNA 3'-end-processing factor FIP1
    Names
    FIP1 like 1
    FIP1-like 1 protein
    FIP1L1 cleavage and polyadenylation specific factor subunit
    factor interacting with PAP
    rearranged in hypereosinophilia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008644.1 RefSeqGene

      Range
      4989..88210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134937.2NP_001128409.1  pre-mRNA 3'-end-processing factor FIP1 isoform 2

      See identical proteins and their annotated locations for NP_001128409.1

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS47055.1
      UniProtKB/TrEMBL
      A0A994J6C9
      Related
      ENSP00000351383.5, ENST00000358575.9
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    2. NM_001134938.2NP_001128410.1  pre-mRNA 3'-end-processing factor FIP1 isoform 3

      See identical proteins and their annotated locations for NP_001128410.1

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS47056.1
      UniProtKB/TrEMBL
      A0A994J6P8
      Related
      ENSP00000302993.6, ENST00000306932.10
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    3. NM_001376744.1NP_001363673.1  pre-mRNA 3'-end-processing factor FIP1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    4. NM_001376745.1NP_001363674.1  pre-mRNA 3'-end-processing factor FIP1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93495.1
      UniProtKB/TrEMBL
      A0A994J6B4, A0A994J6C9
      Related
      ENSP00000515305.1, ENST00000703454.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    5. NM_001376746.1NP_001363675.1  pre-mRNA 3'-end-processing factor FIP1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93499.1
      UniProtKB/TrEMBL
      A0A994J3L5, A0A994J6C9
      Related
      ENSP00000515334.1, ENST00000703484.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    6. NM_001376747.1NP_001363676.1  pre-mRNA 3'-end-processing factor FIP1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93504.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6D6
      Related
      ENSP00000515335.1, ENST00000703485.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    7. NM_001376748.1NP_001363677.1  pre-mRNA 3'-end-processing factor FIP1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93503.1
      UniProtKB/TrEMBL
      A0A994J469, A0A994J6P8
      Related
      ENSP00000515336.1, ENST00000703486.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    8. NM_001376749.1NP_001363678.1  pre-mRNA 3'-end-processing factor FIP1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93501.1
      UniProtKB/TrEMBL
      A0A994J3I9, A0A994J6C9
      Related
      ENSP00000515304.1, ENST00000703453.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    9. NM_001376750.1NP_001363679.1  pre-mRNA 3'-end-processing factor FIP1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93515.1
      UniProtKB/TrEMBL
      A0A994J458, A0A994J6C9
      Related
      ENSP00000515326.1, ENST00000703475.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    10. NM_001376751.1NP_001363680.1  pre-mRNA 3'-end-processing factor FIP1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93510.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6R0
      Related
      ENSP00000515333.1, ENST00000703483.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    11. NM_001376752.1NP_001363681.1  pre-mRNA 3'-end-processing factor FIP1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93502.1
      UniProtKB/TrEMBL
      A0A994J464, A0A994J6C9
      Related
      ENSP00000515331.1, ENST00000703481.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    12. NM_001376753.1NP_001363682.1  pre-mRNA 3'-end-processing factor FIP1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    13. NM_001376754.1NP_001363683.1  pre-mRNA 3'-end-processing factor FIP1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93506.1
      UniProtKB/TrEMBL
      A0A994J474, A0A994J6C9
      Related
      ENSP00000515342.1, ENST00000703492.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    14. NM_001376755.1NP_001363684.1  pre-mRNA 3'-end-processing factor FIP1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93512.1
      UniProtKB/TrEMBL
      A0A994J3T5, A0A994J6C9
      Related
      ENSP00000515343.1, ENST00000703497.1
      Conserved Domains (1) summary
      pfam05182
      Location:153195
      Fip1; Fip1 motif
    15. NM_001376756.1NP_001363685.1  pre-mRNA 3'-end-processing factor FIP1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    16. NM_001376757.1NP_001363686.1  pre-mRNA 3'-end-processing factor FIP1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    17. NM_001376758.1NP_001363687.1  pre-mRNA 3'-end-processing factor FIP1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93519.1
      UniProtKB/TrEMBL
      A0A994J453, A0A994J6P8
      Related
      ENSP00000515321.1, ENST00000703470.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    18. NM_001376759.1NP_001363688.1  pre-mRNA 3'-end-processing factor FIP1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93497.1
      UniProtKB/TrEMBL
      A0A994J3S0, A0A994J6P8
      Related
      ENSP00000515327.1, ENST00000703476.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    19. NM_001376760.1NP_001363689.1  pre-mRNA 3'-end-processing factor FIP1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93518.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6N5
      Related
      ENSP00000515303.1, ENST00000703452.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    20. NM_001376761.1NP_001363690.1  pre-mRNA 3'-end-processing factor FIP1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93500.1
      UniProtKB/TrEMBL
      A0A994J3S6, A0A994J6P8
      Related
      ENSP00000515332.1, ENST00000703482.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    21. NM_001376762.1NP_001363691.1  pre-mRNA 3'-end-processing factor FIP1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    22. NM_001376764.1NP_001363693.1  pre-mRNA 3'-end-processing factor FIP1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93524.1
      UniProtKB/TrEMBL
      A0A994J442, A0A994J6C9
      Related
      ENSP00000515311.1, ENST00000703460.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    23. NM_001376765.1NP_001363694.1  pre-mRNA 3'-end-processing factor FIP1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93498.1
      UniProtKB/TrEMBL
      A0A994J3M0, A0A994J6P8
      Related
      ENSP00000515340.1, ENST00000703490.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    24. NM_001376766.1NP_001363695.1  pre-mRNA 3'-end-processing factor FIP1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93496.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J3Q0
      Related
      ENSP00000515307.1, ENST00000703456.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    25. NM_001376767.1NP_001363696.1  pre-mRNA 3'-end-processing factor FIP1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93520.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6P0
      Related
      ENSP00000515308.1, ENST00000703457.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    26. NM_001376768.1NP_001363697.1  pre-mRNA 3'-end-processing factor FIP1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93525.1
      UniProtKB/TrEMBL
      A0A994J3K5, A0A994J6C9
      Related
      ENSP00000515324.1, ENST00000703473.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    27. NM_001376769.1NP_001363698.1  pre-mRNA 3'-end-processing factor FIP1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93516.1
      UniProtKB/TrEMBL
      A0A994J3R0, A0A994J6P8
      Related
      ENSP00000515317.1, ENST00000703466.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    28. NM_001376770.1NP_001363699.1  pre-mRNA 3'-end-processing factor FIP1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    29. NM_001376771.1NP_001363700.1  pre-mRNA 3'-end-processing factor FIP1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93507.1
      UniProtKB/TrEMBL
      A0A994J438, A0A994J6P8
      Related
      ENSP00000515306.1, ENST00000703455.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    30. NM_001376772.1NP_001363701.1  pre-mRNA 3'-end-processing factor FIP1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93511.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6E2
      Related
      ENSP00000515346.1, ENST00000703500.1
      Conserved Domains (1) summary
      pfam05182
      Location:133160
      Fip1; Fip1 motif
    31. NM_001376773.1NP_001363702.1  pre-mRNA 3'-end-processing factor FIP1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93517.1
      UniProtKB/TrEMBL
      A0A994J3P6, A0A994J6P8
      Related
      ENSP00000515302.1, ENST00000703451.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    32. NM_001376774.1NP_001363703.1  pre-mRNA 3'-end-processing factor FIP1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    33. NM_001376775.1NP_001363704.1  pre-mRNA 3'-end-processing factor FIP1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93509.1
      UniProtKB/TrEMBL
      A0A994J6E0, A0A994J6P8
      Related
      ENSP00000515341.1, ENST00000703491.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    34. NM_001376776.1NP_001363705.1  pre-mRNA 3'-end-processing factor FIP1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    35. NM_001376777.1NP_001363706.1  pre-mRNA 3'-end-processing factor FIP1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    36. NM_001376778.1NP_001363707.1  pre-mRNA 3'-end-processing factor FIP1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93522.1
      UniProtKB/TrEMBL
      A0A994J6P8, H0Y8P7
      Related
      ENSP00000421691.2, ENST00000504094.2
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    37. NM_001376779.1NP_001363708.1  pre-mRNA 3'-end-processing factor FIP1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93521.1
      UniProtKB/TrEMBL
      A0A994J3J1, A0A994J6P8
      Related
      ENSP00000515309.1, ENST00000703458.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    38. NM_001376780.1NP_001363709.1  pre-mRNA 3'-end-processing factor FIP1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93526.1
      UniProtKB/TrEMBL
      A0A994J3R5, A0A994J6P8
      Related
      ENSP00000515322.1, ENST00000703471.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    39. NM_001376781.1NP_001363710.1  pre-mRNA 3'-end-processing factor FIP1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93523.1
      UniProtKB/TrEMBL
      A0A994J3K1, A0A994J6P8
      Related
      ENSP00000515319.1, ENST00000703468.1
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    40. NM_001376782.1NP_001363711.1  pre-mRNA 3'-end-processing factor FIP1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:115157
      Fip1; Fip1 motif
    41. NM_001376783.1NP_001363712.1  pre-mRNA 3'-end-processing factor FIP1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    42. NM_001376784.1NP_001363713.1  pre-mRNA 3'-end-processing factor FIP1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139181
      Fip1; Fip1 motif
    43. NM_001376785.1NP_001363714.1  pre-mRNA 3'-end-processing factor FIP1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
    44. NM_001376786.1NP_001363715.1  pre-mRNA 3'-end-processing factor FIP1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93508.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6Q5
      Related
      ENSP00000515328.1, ENST00000703478.1
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    45. NM_001410723.1NP_001397652.1  pre-mRNA 3'-end-processing factor FIP1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93513.1
      UniProtKB/TrEMBL
      A0A994J6C6, A0A994J6C9
      Related
      ENSP00000515320.1, ENST00000703469.1
    46. NM_001410724.1NP_001397653.1  pre-mRNA 3'-end-processing factor FIP1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93514.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J3Q5
      Related
      ENSP00000515312.1, ENST00000703461.1
    47. NM_030917.4NP_112179.2  pre-mRNA 3'-end-processing factor FIP1 isoform 1

      See identical proteins and their annotated locations for NP_112179.2

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821, AY366510, DN990103
      Consensus CDS
      CCDS3491.1
      UniProtKB/Swiss-Prot
      B4DIR3, G3XAD6, Q0VGE0, Q499Y4, Q49AU3, Q6UN15, Q7Z608, Q8WVN3, Q96F80, Q9H077
      UniProtKB/TrEMBL
      A0A994J6C9
      Related
      ENSP00000336752.6, ENST00000337488.11
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif

    RNA

    1. NR_164847.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
    2. NR_164848.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
    3. NR_164849.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      53377641..53460862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416208.1XP_047272164.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

      UniProtKB/TrEMBL
      A0A994J6C9
    2. XM_005265779.5XP_005265836.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:154196
      Fip1; Fip1 motif
    3. XM_047416211.1XP_047272167.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

      UniProtKB/TrEMBL
      A0A994J6P8
    4. XM_047416212.1XP_047272168.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

      UniProtKB/TrEMBL
      A0A994J6P8
    5. XM_047416218.1XP_047272174.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6D3
      Related
      ENSP00000515330.1, ENST00000703480.1
    6. XM_047416215.1XP_047272171.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

      UniProtKB/TrEMBL
      A0A994J6P8
    7. XM_047416210.1XP_047272166.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

      UniProtKB/TrEMBL
      A0A994J6C9
    8. XM_047416214.1XP_047272170.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

      UniProtKB/TrEMBL
      A0A994J6P8
    9. XM_047416216.1XP_047272172.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

      UniProtKB/TrEMBL
      A0A994J6P8
    10. XM_047416213.1XP_047272169.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

      UniProtKB/TrEMBL
      A0A994J6P8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      56864883..56948080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350921.1XP_054206896.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

      UniProtKB/TrEMBL
      A0A994J6C9
    2. XM_054350927.1XP_054206902.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

      UniProtKB/TrEMBL
      A0A994J3L0
    3. XM_054350923.1XP_054206898.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

      UniProtKB/TrEMBL
      A0A994J6P8
    4. XM_054350924.1XP_054206899.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

      UniProtKB/TrEMBL
      A0A994J6P8
    5. XM_054350930.1XP_054206905.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6D3
    6. XM_054350928.1XP_054206903.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

      UniProtKB/TrEMBL
      A0A994J6P8
    7. XM_054350922.1XP_054206897.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

      UniProtKB/TrEMBL
      A0A994J6C9
    8. XM_054350926.1XP_054206901.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

      UniProtKB/TrEMBL
      A0A994J6P8
    9. XM_054350929.1XP_054206904.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

      UniProtKB/TrEMBL
      A0A994J6P8
    10. XM_054350925.1XP_054206900.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

      UniProtKB/TrEMBL
      A0A994J6P8