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    FOSL1 FOS like 1, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 8061, updated on 9-Jun-2024

    Summary

    Official Symbol
    FOSL1provided by HGNC
    Official Full Name
    FOS like 1, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:13718
    See related
    Ensembl:ENSG00000175592 MIM:136515; AllianceGenome:HGNC:13718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRA; FRA1; fra-1
    Summary
    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in gall bladder (RPKM 16.7), urinary bladder (RPKM 10.2) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FOSL1 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65892049..65900545, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65885111..65893612, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65659520..65668016, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cathepsin W Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5018 Neighboring gene FGF1 intracellular binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5020 Neighboring gene coiled-coil domain containing 85B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65661089-65661593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5021 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65666730-65666957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3567 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5022 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:65682731-65683930 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:65685650-65686569 and GRCh37_chr11:65686570-65687490 Neighboring gene chromosome 11 open reading frame 68 Neighboring gene DR1 associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in placenta blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to gravity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitellogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    fos-related antigen 1
    Names
    FOS like 1, AP-1 trancription factor subunit
    FOS-like antigen-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300844.2NP_001287773.1  fos-related antigen 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, AK299050, AP006287, BM764259, BQ937004
      Consensus CDS
      CCDS73324.1
      UniProtKB/TrEMBL
      E9PPX2, Q53GM9
      Related
      ENSP00000436276.1, ENST00000531493.5
      Conserved Domains (2) summary
      cl21462
      Location:99132
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
      cl28929
      Location:98214
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
    2. NM_001300855.2NP_001287784.1  fos-related antigen 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA120824, AP006287, BC016648, BP222547, BQ937004
      Consensus CDS
      CCDS76437.1
      UniProtKB/TrEMBL
      E9PKL5
      Related
      ENSP00000431594.1, ENST00000532401.1
    3. NM_001300856.2NP_001287785.1  fos-related antigen 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, AP006287, BC016648, BQ937004, CB123614
      UniProtKB/Swiss-Prot
      P15407
      Conserved Domains (2) summary
      PRK13729
      Location:63184
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd14721
      Location:49102
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    4. NM_001300857.2NP_001287786.1  fos-related antigen 1 isoform 5

      See identical proteins and their annotated locations for NP_001287786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, AP006287, BC016648, BM846271, BQ937004
      Consensus CDS
      CCDS76436.1
      UniProtKB/Swiss-Prot
      P15407
      Related
      ENSP00000393302.2, ENST00000448083.6
      Conserved Domains (2) summary
      PRK13729
      Location:35148
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cl21462
      Location:3466
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    5. NM_005438.5NP_005429.1  fos-related antigen 1 isoform 1

      See identical proteins and their annotated locations for NP_005429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA120824, AP006287, BC016648, BQ937004
      Consensus CDS
      CCDS8121.1
      UniProtKB/Swiss-Prot
      B4DR11, P15407, Q6FG51
      UniProtKB/TrEMBL
      A0A0S2Z595, Q53GM9
      Related
      ENSP00000310170.2, ENST00000312562.7
      Conserved Domains (2) summary
      PRK13729
      Location:129250
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd14721
      Location:115168
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RNA

    1. NR_125339.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA120824, AP006287, BC016648, BQ937004

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      65892049..65900545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      65885111..65893612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)