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    ZNF143 zinc finger protein 143 [ Homo sapiens (human) ]

    Gene ID: 7702, updated on 10-Dec-2019

    Summary

    Official Symbol
    ZNF143provided by HGNC
    Official Full Name
    zinc finger protein 143provided by HGNC
    Primary source
    HGNC:HGNC:12928
    See related
    Ensembl:ENSG00000166478 MIM:603433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SBF; STAF; pHZ-1
    Expression
    Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF143 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9460965..9528524)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9482512..9550071)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC644656 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene ribosomal protein L23a pseudogene 65

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 143
    Names
    SPH-binding factor
    hStaf
    selenocysteine tRNA gene transcription-activating factor
    transcriptional activator Staf
    NP_001269585.1
    NP_001269586.1
    NP_003433.3
    XP_005253178.1
    XP_005253179.1
    XP_005253184.1
    XP_011518651.1
    XP_016873741.1
    XP_016873742.1
    XP_016873743.1
    XP_016873744.1
    XP_016873745.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282656.1NP_001269585.1  zinc finger protein 143 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AK297214, AK313330, BF515092, BG825506, CN295530
      Consensus CDS
      CCDS60720.1
      UniProtKB/Swiss-Prot
      P52747
      Related
      ENSP00000432154.1, ENST00000530463.5
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    2. NM_001282657.1NP_001269586.1  zinc finger protein 143 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK297214, BC014458, BF515092, BG825506, CN295530
      Consensus CDS
      CCDS60721.1
      UniProtKB/Swiss-Prot
      P52747
      Related
      ENSP00000379843.3, ENST00000396597.7
      Conserved Domains (5) summary
      COG5048
      Location:233291
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:208230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:282309
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:268383
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:51161
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    3. NM_003442.6NP_003433.3  zinc finger protein 143 isoform 1

      See identical proteins and their annotated locations for NP_003433.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK297214, AW162015, BC020219, BG825506
      Consensus CDS
      CCDS7799.2
      UniProtKB/Swiss-Prot
      P52747
      Related
      ENSP00000379847.2, ENST00000396602.7
      Conserved Domains (5) summary
      COG5048
      Location:264322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313340
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:299414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:82192
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      9460965..9528524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018256.1XP_016873745.1  zinc finger protein 143 isoform X7

    2. XM_017018252.1XP_016873741.1  zinc finger protein 143 isoform X3

    3. XM_017018253.1XP_016873742.1  zinc finger protein 143 isoform X4

    4. XM_005253122.1XP_005253179.1  zinc finger protein 143 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:278336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253275
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:327354
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:313428
      zf-C2H2_8; C2H2-type zinc ribbon
    5. XM_005253127.1XP_005253184.1  zinc finger protein 143 isoform X8

      Conserved Domains (4) summary
      COG5048
      Location:61119
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:3658
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:110137
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:96211
      zf-C2H2_8; C2H2-type zinc ribbon
    6. XM_005253121.1XP_005253178.1  zinc finger protein 143 isoform X1

      Conserved Domains (5) summary
      COG5048
      Location:279337
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:328355
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:314429
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:97207
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    7. XM_011520349.2XP_011518651.1  zinc finger protein 143 isoform X5

      See identical proteins and their annotated locations for XP_011518651.1

      UniProtKB/Swiss-Prot
      P52747
      Conserved Domains (5) summary
      COG5048
      Location:264322
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313340
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:299414
      zf-C2H2_8; C2H2-type zinc ribbon
      cl00342
      Location:82192
      Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
    8. XM_017018254.2XP_016873743.1  zinc finger protein 143 isoform X6

      UniProtKB/Swiss-Prot
      P52747
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
    9. XM_017018255.1XP_016873744.1  zinc finger protein 143 isoform X6

      UniProtKB/Swiss-Prot
      P52747
      Conserved Domains (4) summary
      COG5048
      Location:263321
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:312339
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:298413
      zf-C2H2_8; C2H2-type zinc ribbon
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