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    USF2 upstream transcription factor 2, c-fos interacting [ Homo sapiens (human) ]

    Gene ID: 7392, updated on 9-Jun-2024

    Summary

    Official Symbol
    USF2provided by HGNC
    Official Full Name
    upstream transcription factor 2, c-fos interactingprovided by HGNC
    Primary source
    HGNC:HGNC:12594
    See related
    Ensembl:ENSG00000105698 MIM:600390; AllianceGenome:HGNC:12594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIP; bHLHb12
    Summary
    This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See USF2 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35268962..35279821)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37813633..37824489)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35759865..35770724)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14461 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35738792-35739594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35739595-35740396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35748323-35748823 Neighboring gene uncharacterized LOC105372380 Neighboring gene lipolysis stimulated lipoprotein receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35753027-35753725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35761221-35761960 Neighboring gene HNF4 motif-containing MPRA enhancer 344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    upstream stimulatory factor 2
    Names
    c-fos interacting protein
    class B basic helix-loop-helix protein 12
    major late transcription factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029241.1 RefSeqGene

      Range
      4970..15829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321150.2NP_001308079.1  upstream stimulatory factor 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AD000684, AI240594, AY147880
      Consensus CDS
      CCDS82329.1
      UniProtKB/Swiss-Prot
      Q15853
      Related
      ENSP00000368429.3, ENST00000379134.7
      Conserved Domains (2) summary
      cd00083
      Location:102164
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      TIGR04211
      Location:135202
      SH3_and_anchor; SH3 domain protein
    2. NM_003367.4NP_003358.1  upstream stimulatory factor 2 isoform 1

      See identical proteins and their annotated locations for NP_003358.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AD000684, AI240594, AY007087, BC049821, X90825
      Consensus CDS
      CCDS12452.1
      UniProtKB/Swiss-Prot
      O00671, O00709, Q05750, Q07952, Q15851, Q15852, Q15853, Q6FI33, Q6YI47
      UniProtKB/TrEMBL
      B4DLJ1
      Related
      ENSP00000222305.2, ENST00000222305.8
      Conserved Domains (2) summary
      cd18923
      Location:229308
      bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
      pfam06005
      Location:290334
      ZapB; Cell division protein ZapB
    3. NM_207291.3NP_997174.1  upstream stimulatory factor 2 isoform 2

      See identical proteins and their annotated locations for NP_997174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AD000684, AI240594, AY007087, X90825
      Consensus CDS
      CCDS12453.1
      UniProtKB/Swiss-Prot
      Q15853
      Related
      ENSP00000340633.4, ENST00000343550.9
      Conserved Domains (2) summary
      cd18923
      Location:162241
      bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
      pfam06005
      Location:223267
      ZapB; Cell division protein ZapB

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35268962..35279821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259197.5XP_005259254.1  upstream stimulatory factor 2 isoform X1

      UniProtKB/TrEMBL
      B4DLJ1
      Related
      ENSP00000471511.1, ENST00000594064.5
      Conserved Domains (1) summary
      cd18923
      Location:229308
      bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
    2. XM_011527260.3XP_011525562.1  upstream stimulatory factor 2 isoform X2

    3. XM_011527261.3XP_011525563.1  upstream stimulatory factor 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37813633..37824489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321938.1XP_054177913.1  upstream stimulatory factor 2 isoform X1

      UniProtKB/TrEMBL
      B4DLJ1
    2. XM_054321939.1XP_054177914.1  upstream stimulatory factor 2 isoform X2

    3. XM_054321940.1XP_054177915.1  upstream stimulatory factor 2 isoform X3