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    Ago2 argonaute RISC catalytic component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59117, updated on 11-Jun-2019

    Summary

    Official Symbol
    Ago2provided by RGD
    Official Full Name
    argonaute RISC catalytic component 2provided by RGD
    Primary source
    RGD:621255
    See related
    Ensembl:ENSRNOG00000008533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif2c2
    Summary
    may have important roles in development and exert the effects on cell differentiation from the level of intracellular membranes [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Spleen (RPKM 251.5), Muscle (RPKM 174.4) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ago2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (114339607..114377277, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (114274582..114312135, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 9 Neighboring gene retinoic acid early transcript 1L Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151b Neighboring gene microRNA 151 Neighboring gene similar to ribosomal protein L36

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RNA 7-methylguanosine cap binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA 7-methylguanosine cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    core promoter binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoribonuclease activity, cleaving miRNA-paired mRNA IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity, cleaving miRNA-paired mRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoribonuclease activity, cleaving siRNA-paired mRNA IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity, cleaving siRNA-paired mRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoribonuclease activity, cleaving siRNA-paired mRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mRNA cap binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    molecular_function ND
    No biological Data available
    more info
     
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    siRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    siRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    contributes_to siRNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    siRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA phosphodiester bond hydrolysis, endonucleolytic IEA
    Inferred from Electronic Annotation
    more info
     
    RNA secondary structure unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    gene silencing by RNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gene silencing by RNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA cleavage involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cleavage involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mRNA cleavage involved in gene silencing by miRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA cleavage involved in gene silencing by siRNA IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cleavage involved in gene silencing by siRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    miRNA loading onto RISC involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    miRNA mediated inhibition of translation IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    miRNA mediated inhibition of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    miRNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of amyloid precursor protein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of miRNA mediated inhibition of translation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    pre-miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    siRNA loading onto RISC involved in RNA interference IEA
    Inferred from Electronic Annotation
    more info
     
    siRNA loading onto RISC involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    P-body IEA
    Inferred from Electronic Annotation
    more info
     
    P-body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RISC complex IEA
    Inferred from Electronic Annotation
    more info
     
    RISC complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RISC-loading complex IEA
    Inferred from Electronic Annotation
    more info
     
    RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RISC-loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mRNA cap binding complex IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mRNA cap binding complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    polysome IEA
    Inferred from Electronic Annotation
    more info
     
    polysome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    polysome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein argonaute-2
    Names
    GERp95
    argonaute 2, RISC catalytic component
    argonaute2
    eIF-2C 2
    eIF2C 2
    eukaryotic translation initiation factor 2C 2
    golgi ER protein 95 kDa
    NP_067608.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021597.1NP_067608.1  protein argonaute-2

      See identical proteins and their annotated locations for NP_067608.1

      Status: PROVISIONAL

      Source sequence(s)
      AF195534
      UniProtKB/Swiss-Prot
      Q9QZ81
      Related
      ENSRNOP00000011898.3, ENSRNOT00000011898.4
      Conserved Domains (5) summary
      PLN03202
      Location:10862
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:231351
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:396821
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:181230
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:32170
      ArgoN; N-terminal domain of argonaute

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      114339607..114377277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      101439261..101476737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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