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    ZNF304 zinc finger protein 304 [ Homo sapiens (human) ]

    Gene ID: 57343, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF304provided by HGNC
    Official Full Name
    zinc finger protein 304provided by HGNC
    Primary source
    HGNC:HGNC:13505
    See related
    Ensembl:ENSG00000131845 MIM:613840; AllianceGenome:HGNC:13505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein functions as a transcriptional repressor that recruits a corepressor complex to stimulate promoter hypermethylation and transcriptional silencing of target genes. Expression of this gene is upregulated in colorectal, ovarian and breast cancer, and this gene may promote cancer cell survival, growth and invasion. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.2), spleen (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF304 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57351271..57359898)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60448301..60456928)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57862639..57871266)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPPDE peptidase domain containing 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:57830216-57830733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15132 Neighboring gene zinc finger protein 543 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57861815-57862674 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:57862675-57863533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15136 Neighboring gene trafficking protein particle complex subunit 2B Neighboring gene zinc finger protein 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15138 Neighboring gene zinc finger protein 548

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC129703, MGC129704

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 304
    Names
    KRAB-containing zinc finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051201.1 RefSeqGene

      Range
      5019..13646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290318.2NP_001277247.1  zinc finger protein 304 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC005261, BC111532, BP315423
      Consensus CDS
      CCDS77365.1
      UniProtKB/TrEMBL
      E7EQD3
      Related
      ENSP00000401642.2, ENST00000443917.6
      Conserved Domains (3) summary
      COG5048
      Location:325680
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1353
      KRAB; KRAB box
    2. NM_001290319.2NP_001277248.1  zinc finger protein 304 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC005261, BC111531, BP315423
      Consensus CDS
      CCDS74462.1
      UniProtKB/TrEMBL
      M0QZ59
      Related
      ENSP00000470319.1, ENST00000598744.1
      Conserved Domains (3) summary
      COG5048
      Location:236591
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:295315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:307332
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001329456.2NP_001316385.1  zinc finger protein 304 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC005261
    4. NM_020657.4NP_065708.2  zinc finger protein 304 isoform 2

      See identical proteins and their annotated locations for NP_065708.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC005261, BC111532, BP315423
      Consensus CDS
      CCDS12950.1
      UniProtKB/Swiss-Prot
      Q9HCX3
      Related
      ENSP00000282286.4, ENST00000282286.6
      Conserved Domains (5) summary
      smart00349
      Location:1455
      KRAB; krueppel associated box
      COG5048
      Location:278633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:337357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:349374
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57351271..57359898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527145.3XP_011525447.1  zinc finger protein 304 isoform X1

      See identical proteins and their annotated locations for XP_011525447.1

      Conserved Domains (3) summary
      COG5048
      Location:283638
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:342362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:354379
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60448301..60456928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321521.1XP_054177496.1  zinc finger protein 304 isoform X1