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    CAMK1D calcium/calmodulin dependent protein kinase ID [ Homo sapiens (human) ]

    Gene ID: 57118, updated on 7-Jul-2019

    Summary

    Official Symbol
    CAMK1Dprovided by HGNC
    Official Full Name
    calcium/calmodulin dependent protein kinase IDprovided by HGNC
    Primary source
    HGNC:HGNC:19341
    See related
    Ensembl:ENSG00000183049 MIM:607957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLiK; CaM-K1; CaMKID
    Summary
    This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues See more
    Orthologs

    Genomic context

    See CAMK1D in Genome Data Viewer
    Location:
    10p13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (12349514..12835545)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (12391583..12871735)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FOXA motif-containing MPRA enhancer 241 Neighboring gene cell division cycle 123 Neighboring gene RNA, 7SL, cytoplasmic 198, pseudogene Neighboring gene RNA, U6atac small nuclear 39, pseudogene Neighboring gene uncharacterized LOC107984209 Neighboring gene microRNA 4480 Neighboring gene microRNA 4481 Neighboring gene microRNA 548q Neighboring gene uncharacterized LOC105376418 Neighboring gene 10p13 CCDC3 distal Alu-mediated recombination region Neighboring gene RNA, 5S ribosomal pseudogene 300 Neighboring gene coiled-coil domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    NHGRI GWA Catalog
    Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
    NHGRI GWA Catalog
    Genetic variants associated with disordered eating.
    NHGRI GWA Catalog
    Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.
    NHGRI GWA Catalog
    Identification of new genetic risk variants for type 2 diabetes.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of calcium/calmodulin-dependent protein kinase ID (CAMK1D) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
      Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
      Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ40058

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of respiratory burst IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of granulocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1D
    Names
    CAMK1D/ANAPC5 fusion
    CaM kinase ID
    CamKI-like protein kinase
    caM kinase I delta
    caM-KI delta
    caMKI delta
    NP_001337961.1
    NP_065130.1
    NP_705718.1
    XP_006717545.1
    XP_006717546.1
    XP_011517893.1
    XP_011517894.1
    XP_011517895.1
    XP_011517896.1
    XP_011517897.1
    XP_016871927.1
    XP_024303855.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351032.2NP_001337961.1  calcium/calmodulin-dependent protein kinase type 1D isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA903749, AF286366, AK289393, AL391314, AL512783, BQ059621, HY156642
      Conserved Domains (1) summary
      cl21453
      Location:1215
      PKc_like; Protein Kinases, catalytic domain
    2. NM_020397.4NP_065130.1  calcium/calmodulin-dependent protein kinase type 1D isoform 1

      See identical proteins and their annotated locations for NP_065130.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks the 3' terminal exon used in variant 2, and its 3' terminal exon extends past a splice site that is used in variant 2. It encodes isoform 1, which has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AA903749, AF286366, AK289393, AL512783, BQ059621, HY168807
      Consensus CDS
      CCDS7092.1
      UniProtKB/Swiss-Prot
      Q8IU85
      UniProtKB/TrEMBL
      Q5SQQ7
      Related
      ENSP00000368122.1, ENST00000378845.5
      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
    3. NM_153498.4NP_705718.1  calcium/calmodulin-dependent protein kinase type 1D isoform 2

      See identical proteins and their annotated locations for NP_705718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AB081726, AK289393, AL512783, BC035745, BC073155, HY168807, KF510334
      Consensus CDS
      CCDS7091.1
      UniProtKB/Swiss-Prot
      Q8IU85
      UniProtKB/TrEMBL
      Q5SQQ7
      Related
      ENSP00000478874.1, ENST00000619168.4
      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      12349514..12835545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717482.3XP_006717545.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:23279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
    2. XM_017016438.2XP_016871927.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1215
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006717483.4XP_006717546.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

      See identical proteins and their annotated locations for XP_006717546.1

      Conserved Domains (1) summary
      cd14168
      Location:12312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta
    4. XM_011519591.3XP_011517893.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:18266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:18265
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
    5. XM_024448087.1XP_024303855.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:1215
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011519595.3XP_011517897.1  calcium/calmodulin-dependent protein kinase type 1D isoform X6

      See identical proteins and their annotated locations for XP_011517897.1

      Related
      ENSP00000478861.1, ENST00000615792.1
      Conserved Domains (1) summary
      cl21453
      Location:1215
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011519593.3XP_011517895.1  calcium/calmodulin-dependent protein kinase type 1D isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:1205
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:2238
      PKc_like; Protein Kinases, catalytic domain
    8. XM_011519592.3XP_011517894.1  calcium/calmodulin-dependent protein kinase type 1D isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:6209
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:6242
      PKc_like; Protein Kinases, catalytic domain
    9. XM_011519594.3XP_011517896.1  calcium/calmodulin-dependent protein kinase type 1D isoform X7

      Conserved Domains (2) summary
      smart00220
      Location:1142
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1175
      PKc_like; Protein Kinases, catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_027322.1: Suppressed sequence

      Description
      NR_027322.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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