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    DUS3L dihydrouridine synthase 3 like [ Homo sapiens (human) ]

    Gene ID: 56931, updated on 6-Jun-2024

    Summary

    Official Symbol
    DUS3Lprovided by HGNC
    Official Full Name
    dihydrouridine synthase 3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:26920
    See related
    Ensembl:ENSG00000141994 AllianceGenome:HGNC:26920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUS3
    Summary
    Enables RNA binding activity. Predicted to be involved in tRNA dihydrouridine synthesis. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 13.5), bone marrow (RPKM 10.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DUS3L in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5785140..5791163, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5771937..5778591, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5785151..5791174, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5780743-5780921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13816 Neighboring gene proline rich 22 Neighboring gene Sharpr-MPRA regulatory region 11822 Neighboring gene neurturin Neighboring gene Sharpr-MPRA regulatory region 2060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5827746-5828434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9936 Neighboring gene fucosyltransferase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like
    Names
    mRNA-dihydrouridine synthase DUS3L
    NP_001155091.1
    NP_064560.2
    XP_016882509.1
    XP_047295067.1
    XP_054177483.1
    XP_054177484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161619.2NP_001155091.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 2

      See identical proteins and their annotated locations for NP_001155091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC004549
      Consensus CDS
      CCDS54202.1
      UniProtKB/Swiss-Prot
      Q96G46
      Related
      ENSP00000315558.7, ENST00000320699.12
      Conserved Domains (2) summary
      COG0042
      Location:55334
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:64296
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    2. NM_020175.3NP_064560.2  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform 1

      See identical proteins and their annotated locations for NP_064560.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011499, AK315691, BC008362
      Consensus CDS
      CCDS32880.1
      UniProtKB/Swiss-Prot
      Q96G46, Q96HM5, Q9BSU4, Q9H877, Q9NPR1
      UniProtKB/TrEMBL
      B2RDV7
      Related
      ENSP00000311977.5, ENST00000309061.12
      Conserved Domains (2) summary
      COG0042
      Location:297576
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd02801
      Location:306538
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      5785140..5791163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027020.2XP_016882509.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

      UniProtKB/TrEMBL
      B2RDV7
    2. XM_047439111.1XP_047295067.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X2

    RNA

    1. XR_244033.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      5771937..5778591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321508.1XP_054177483.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X1

      UniProtKB/TrEMBL
      B2RDV7
    2. XM_054321509.1XP_054177484.1  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like isoform X2

    RNA

    1. XR_008485167.1 RNA Sequence