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    NANOS1 nanos C2HC-type zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 340719, updated on 2-May-2024

    Summary

    Official Symbol
    NANOS1provided by HGNC
    Official Full Name
    nanos C2HC-type zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:23044
    See related
    Ensembl:ENSG00000188613 MIM:608226; AllianceGenome:HGNC:23044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOS1; NOS-1; SPGF12; EC_Rep1a; ZC2HC12A
    Summary
    This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
    Orthologs
    NEW
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    Genomic context

    See NANOS1 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119029714..119033730)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119925128..119929140)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120789226..120793242)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3036 Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120654814-120655422 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120718457-120719187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120719188-120719917 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120781819-120782461 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120782462-120783104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120784290-120784863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120788503-120789003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2866 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene small nucleolar RNA, H/ACA box 19

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cerebellar neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050764.1 RefSeqGene

      Range
      4999..9015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_199461.4NP_955631.1  nanos homolog 1

      See identical proteins and their annotated locations for NP_955631.1

      Status: REVIEWED

      Source sequence(s)
      AF458985, AL157788
      Consensus CDS
      CCDS7607.1
      UniProtKB/Swiss-Prot
      Q8WY41
      Related
      ENSP00000393275.1, ENST00000425699.3
      Conserved Domains (1) summary
      pfam05741
      Location:214266
      zf-nanos; Nanos RNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119029714..119033730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      119925128..119929140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009553.1: Suppressed sequence

      Description
      NM_001009553.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.