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    HGF hepatocyte growth factor [ Homo sapiens (human) ]

    Gene ID: 3082, updated on 17-Oct-2021

    Summary

    Official Symbol
    HGFprovided by HGNC
    Official Full Name
    hepatocyte growth factorprovided by HGNC
    Primary source
    HGNC:HGNC:4893
    See related
    Ensembl:ENSG00000019991 MIM:142409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SF; HGFB; HPTA; F-TCF; DFNB39
    Summary
    This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HGF in Genome Data Viewer
    Location:
    7q21.11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (81699006..81770438, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81328326..81399363, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369146 Neighboring gene uncharacterized LOC100128317 Neighboring gene DEAD-box helicase 43 pseudogene 3 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene CACNA2D1 antisense RNA 1 Neighboring gene uncharacterized LOC107986813

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC) PubMed
    Vpu vpu The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables growth factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of osteoblast differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NOT involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    hepatocyte growth factor
    Names
    fibroblast-derived tumor cytotoxic factor
    hepatocyte growth factor (hepapoietin A; scatter factor)
    hepatopoietin-A
    lung fibroblast-derived mitogen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016274.2 RefSeqGene

      Range
      5090..76127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000601.6NP_000592.3  hepatocyte growth factor isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_000592.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004960, AV701693, BU533235, BX495370, M29145, M73240
      Consensus CDS
      CCDS5597.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000222390.5, ENST00000222390.11
      Conserved Domains (4) summary
      smart00020
      Location:494716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:210290
      KR; Kringle domain
      cd00108
      Location:388470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    2. NM_001010931.3NP_001010931.1  hepatocyte growth factor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001010931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.
      Source sequence(s)
      BM971901, BU533235, BX495370, L02931
      Consensus CDS
      CCDS47627.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000389854.2, ENST00000444829.7
      Conserved Domains (2) summary
      smart00130
      Location:210289
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    3. NM_001010932.3NP_001010932.1  hepatocyte growth factor isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_001010932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) lacks a portion of the alpha chain and is shorter compared to isoform 1.
      Source sequence(s)
      AC004960, AV701693, BU533235, BX495370, M73240
      Consensus CDS
      CCDS47626.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000391238.2, ENST00000457544.7
      Conserved Domains (4) summary
      smart00020
      Location:489711
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:205285
      KR; Kringle domain
      cd00108
      Location:383465
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    4. NM_001010933.3NP_001010933.1  hepatocyte growth factor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001010933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC022308, BM971901, BU533235, BX495370, L02931
      Consensus CDS
      CCDS47628.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000408270.1, ENST00000453411.6
      Conserved Domains (2) summary
      smart00130
      Location:205284
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    5. NM_001010934.3NP_001010934.1  hepatocyte growth factor isoform 5 precursor

      See identical proteins and their annotated locations for NP_001010934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC063485, BU533235, BX495370, U46010
      Consensus CDS
      CCDS47629.1
      UniProtKB/Swiss-Prot
      P14210
      Related
      ENSP00000413829.2, ENST00000423064.7
      Conserved Domains (2) summary
      smart00130
      Location:126208
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      81699006..81770438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715956.2XP_006716019.1  hepatocyte growth factor isoform X1

      See identical proteins and their annotated locations for XP_006716019.1

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (4) summary
      smart00020
      Location:494716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:210290
      KR; Kringle domain
      cd00108
      Location:388470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    2. XM_011516115.2XP_011514417.1  hepatocyte growth factor isoform X2

      See identical proteins and their annotated locations for XP_011514417.1

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (4) summary
      smart00020
      Location:489711
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:205285
      KR; Kringle domain
      cd00108
      Location:383465
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    3. XM_017012098.1XP_016867587.1  hepatocyte growth factor isoform X4

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (2) summary
      smart00130
      Location:205284
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    4. XM_017012097.1XP_016867586.1  hepatocyte growth factor isoform X3

      UniProtKB/Swiss-Prot
      P14210
      Conserved Domains (2) summary
      smart00130
      Location:210289
      KR; Kringle domain
      cd00129
      Location:39122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
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