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    PDS5A PDS5 cohesin associated factor A [ Homo sapiens (human) ]

    Gene ID: 23244, updated on 6-Oct-2024

    Summary

    Official Symbol
    PDS5Aprovided by HGNC
    Official Full Name
    PDS5 cohesin associated factor Aprovided by HGNC
    Primary source
    HGNC:HGNC:29088
    See related
    Ensembl:ENSG00000121892 MIM:613200; AllianceGenome:HGNC:29088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIG54; SCC112; SCC-112
    Summary
    The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.1), lymph node (RPKM 17.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PDS5A in Genome Data Viewer
    Location:
    4p14
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (39822863..39977911, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (39792793..39947875, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39824483..39979531, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 K Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15372 Neighboring gene RNA, 7SL, cytoplasmic 558, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:39787697-39788198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:39788199-39788698 Neighboring gene zinc finger and BTB domain containing 12B, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:39821819-39822356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21469 Neighboring gene RNA, 5S ribosomal pseudogene 159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21470 Neighboring gene Sharpr-MPRA regulatory region 4409 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:39977870-39978778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:39991585-39992282 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:40000455-40000959 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40001597-40002110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:40002111-40002626 Neighboring gene poly(A) binding protein cytoplasmic 1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:40002627-40003140 Neighboring gene keratin 18 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15377 Neighboring gene acyl-CoA thioesterase 7 pseudogene Neighboring gene NEDD4 binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with PDS5A in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ41012, KIAA0648, MGC131948, MGC161503, DKFZp686B19246

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic sister chromatid cohesion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome TAS
    Traceable Author Statement
    more info
     
    located_in chromosome, centromeric region TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    sister chromatid cohesion protein PDS5 homolog A
    Names
    PDS5, regulator of cohesion maintenance, homolog A
    cell proliferation-inducing gene 54 protein
    sister chromatid cohesion protein 112

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021172.1 RefSeqGene

      Range
      5046..160094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001100399.2NP_001093869.1  sister chromatid cohesion protein PDS5 homolog A isoform 1

      See identical proteins and their annotated locations for NP_001093869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC098591, BC041361, BC114218
      Consensus CDS
      CCDS47045.1
      UniProtKB/Swiss-Prot
      Q29RF7, Q2TTR5, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
      UniProtKB/TrEMBL
      G1UI16
      Related
      ENSP00000303427.8, ENST00000303538.13
      Conserved Domains (2) summary
      sd00044
      Location:283313
      HEAT; HEAT repeat [structural motif]
      cd19953
      Location:41671
      PDS5; Sister chromatid cohesion protein PDS5
    2. NM_001100400.2NP_001093870.1  sister chromatid cohesion protein PDS5 homolog A isoform 3

      See identical proteins and their annotated locations for NP_001093870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks several exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC098591, BC041361
      Consensus CDS
      CCDS54759.1
      UniProtKB/Swiss-Prot
      Q29RF7
      Related
      ENSP00000426749.1, ENST00000503396.5
      Conserved Domains (1) summary
      sd00044
      Location:283313
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      39822863..39977911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513672.3XP_011511974.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

      See identical proteins and their annotated locations for XP_011511974.1

      UniProtKB/Swiss-Prot
      Q29RF7, Q2TTR5, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
      UniProtKB/TrEMBL
      G1UI16
      Conserved Domains (2) summary
      sd00044
      Location:283313
      HEAT; HEAT repeat [structural motif]
      cd19953
      Location:41671
      PDS5; Sister chromatid cohesion protein PDS5
    2. XM_047449932.1XP_047305888.1  sister chromatid cohesion protein PDS5 homolog A isoform X3

    3. XM_047449931.1XP_047305887.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

      UniProtKB/Swiss-Prot
      Q29RF7, Q2TTR5, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
      UniProtKB/TrEMBL
      G1UI16

    RNA

    1. XR_001741185.2 RNA Sequence

    2. XR_001741188.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      39792793..39947875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349456.1XP_054205431.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

      UniProtKB/Swiss-Prot
      Q29RF7, Q2TTR5, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
      UniProtKB/TrEMBL
      G1UI16
    2. XM_054349458.1XP_054205433.1  sister chromatid cohesion protein PDS5 homolog A isoform X3

    3. XM_054349457.1XP_054205432.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

      UniProtKB/Swiss-Prot
      Q29RF7, Q2TTR5, Q68DF7, Q8N7J4, Q8NG14, Q9Y4D4
      UniProtKB/TrEMBL
      G1UI16

    RNA

    1. XR_008486958.1 RNA Sequence

    2. XR_008486959.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015200.2: Suppressed sequence

      Description
      NM_015200.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.