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    DHX36 DEAH-box helicase 36 [ Homo sapiens (human) ]

    Gene ID: 170506, updated on 17-Jun-2024

    Summary

    Official Symbol
    DHX36provided by HGNC
    Official Full Name
    DEAH-box helicase 36provided by HGNC
    Primary source
    HGNC:HGNC:14410
    See related
    Ensembl:ENSG00000174953 MIM:612767; AllianceGenome:HGNC:14410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G4R1; RHAU; DDX36; MLEL1
    Summary
    This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 24.2), thyroid (RPKM 15.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DHX36 in Genome Data Viewer
    Location:
    3q25.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (154272546..154324487, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (157046825..157098745, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153990335..154042276, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_65370 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC105374167 Neighboring gene MPRA-validated peak4869 silencer Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene small nucleolar RNA U13 Neighboring gene G protein-coupled receptor 149 Neighboring gene DEAD-box helicase 50 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, DEAH (Asp-Glu-Ala-His) box polypeptide 36 (DHX36), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DHX36 is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1488

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-quadruplex DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-quadruplex RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-quadruplex RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-quadruplex RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pre-miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables telomerase RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G-quadruplex DNA unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA secondary structure unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to arsenite ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardioblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of hematopoietic progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular mRNA localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myeloid dendritic cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomere lengthening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to exogenous dsRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomerase RNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ATP-dependent DNA/RNA helicase DHX36
    Names
    ATP-dependent RNA helicase DHX36
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36
    DEAD/H box polypeptide 36
    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    DEAH box protein 36
    G4 resolvase-1
    MLE-like protein 1
    RNA helicase associated with AU-rich element ARE
    RNA helicase associated with AU-rich element protein
    probable ATP-dependent RNA helicase DHX36
    NP_001107869.1
    NP_065916.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114397.2NP_001107869.1  ATP-dependent DNA/RNA helicase DHX36 isoform 2

      See identical proteins and their annotated locations for NP_001107869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1, resulting in a shorter protein (isoform 2). Isoform 2 localizes to the cytoplasm.
      Source sequence(s)
      AC018452, AJ577134, AK314435, BC036035
      Consensus CDS
      CCDS54657.1
      UniProtKB/TrEMBL
      B7Z8P5
      Related
      ENSP00000330113.5, ENST00000329463.9
      Conserved Domains (5) summary
      smart00487
      Location:210392
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:662746
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:224369
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:476592
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:786903
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. NM_020865.3NP_065916.2  ATP-dependent DNA/RNA helicase DHX36 isoform 1

      See identical proteins and their annotated locations for NP_065916.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Isoform 1 localizes to the nucleus and cytoplasm.
      Source sequence(s)
      AC018452, AK314435, BC036035
      Consensus CDS
      CCDS3171.1
      UniProtKB/Swiss-Prot
      B2RB00, Q70JU3, Q8IYE5, Q9H2U1, Q9P240
      UniProtKB/TrEMBL
      B7Z8P5
      Related
      ENSP00000417078.1, ENST00000496811.6
      Conserved Domains (5) summary
      smart00487
      Location:210392
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:676760
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:224369
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:476606
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:800917
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      154272546..154324487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187533.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1179..9497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      157046825..157098745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)