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    CREB3L4 cAMP responsive element binding protein 3 like 4 [ Homo sapiens (human) ]

    Gene ID: 148327, updated on 23-Nov-2021

    Summary

    Official Symbol
    CREB3L4provided by HGNC
    Official Full Name
    cAMP responsive element binding protein 3 like 4provided by HGNC
    Primary source
    HGNC:HGNC:18854
    See related
    Ensembl:ENSG00000143578 MIM:607138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
    Summary
    This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CREB3L4 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153967487..153974364)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153940378..153946835)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene solute carrier family 39 member 1 Neighboring gene microRNA 6737 Neighboring gene Sharpr-MPRA regulatory region 11874 Neighboring gene jumping translocation breakpoint Neighboring gene RAB13, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclic AMP-responsive element-binding protein 3-like protein 4
    Names
    CREB-4
    androgen-induced basic leucine zipper protein
    attaching to CRE-like 1
    cAMP responsive element binding protein 1
    cAMP-responsive element-binding protein 3-like protein 4
    cAMP-responsive element-binding protein 4
    cyclic AMP-responsive element-binding protein 4
    tisp40
    transcript induced in spermiogenesis protein 40

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001255978.2NP_001242907.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AY049977, DB012316
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Related
      ENSP00000357596.3, ENST00000368607.8
      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001255979.2NP_001242908.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001242908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA652478, AF394167, AF468007
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Related
      ENSP00000357592.1, ENST00000368603.5
      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001255980.2NP_001242909.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001242909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
      Source sequence(s)
      AA652478, AK304665, DB012316
      Consensus CDS
      CCDS58029.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    4. NM_001255981.2NP_001242910.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001242910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
      Source sequence(s)
      AL358472, BX647716
      Consensus CDS
      CCDS58029.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Related
      ENSP00000357589.3, ENST00000368600.7
      Conserved Domains (1) summary
      cd14689
      Location:198258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    5. NM_130898.4NP_570968.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_570968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA652478, AB052778, DB012316
      Consensus CDS
      CCDS1056.1
      UniProtKB/Swiss-Prot
      Q8TEY5
      Related
      ENSP00000271889.4, ENST00000271889.8
      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    RNA

    1. NR_045658.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA652478, AK297703, BF681098, DB012316

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      153967487..153974364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453343.1XP_024309111.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    2. XM_024453344.1XP_024309112.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    3. XM_017000372.1XP_016855861.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    4. XM_006711172.2XP_006711235.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006711235.1

      UniProtKB/Swiss-Prot
      Q8TEY5
      Conserved Domains (1) summary
      cd14689
      Location:198258
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
    5. XM_024453346.1XP_024309114.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

      Conserved Domains (2) summary
      TIGR00864
      Location:77154
      PCC; polycystin cation channel protein
      cd14689
      Location:218278
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
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