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    YDJ1 type I HSP40 co-chaperone YDJ1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855661, updated on 22-May-2018
    Gene symbol
    YDJ1
    Gene description
    type I HSP40 co-chaperone YDJ1
    Primary source
    SGD:S000005008
    Locus tag
    YNL064C
    Gene type
    protein coding
    RNA name
    type I HSP40 co-chaperone YDJ1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSP40; MAB3; MAS5
    See YDJ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (505868..507097, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative glucosidase SUN4 Neighboring gene Aqr1p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene tRNA 1-methyladenosine methyltransferase subunit GCD10

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    TRC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol HDA PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    type I HSP40 co-chaperone YDJ1
    NP_014335.1
    • Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      505868..507097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182902.1NP_014335.1  TPA: type I HSP40 co-chaperone YDJ1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014335.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25491
      Conserved Domains (4) summary
      cd10719
      Location:143208
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:114338
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:2368
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:767
      DnaJ; DnaJ domain
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