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    MAGEB3 MAGE family member B3 [ Homo sapiens (human) ]

    Gene ID: 4114, updated on 4-Feb-2018
    Official Symbol
    MAGEB3provided by HGNC
    Official Full Name
    MAGE family member B3provided by HGNC
    Primary source
    HGNC:HGNC:6810
    See related
    Ensembl:ENSG00000198798 MIM:300152; Vega:OTTHUMG00000021320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT3.5
    Summary
    This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 3.0) See more
    Orthologs
    Location:
    Xp21.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (30230436..30237493)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30248553..30255612)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985632 Neighboring gene MAGE family member B2 Neighboring gene MAGE family member B4 Neighboring gene MAGE family member B1 Neighboring gene phospholipase C epsilon 1 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Preferred Names
    melanoma-associated antigen B3
    Names
    MAGE-B3 antigen
    cancer/testis antigen family 3, member 5
    melanoma antigen family B, 3
    melanoma antigen family B3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015869.1 RefSeqGene

      Range
      5001..12058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002365.4NP_002356.2  melanoma-associated antigen B3

      See identical proteins and their annotated locations for NP_002356.2

      Status: REVIEWED

      Source sequence(s)
      AA934059, AK057441, BC069784
      Consensus CDS
      CCDS14220.1
      UniProtKB/Swiss-Prot
      O15480
      Related
      ENSP00000355198.2, OTTHUMP00000023099, ENST00000361644.3, OTTHUMT00000056158
      Conserved Domains (2) summary
      pfam01454
      Location:129286
      MAGE; MAGE family
      pfam12440
      Location:593
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      30230436..30237493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545514.2XP_011543816.1  melanoma-associated antigen B3 isoform X1

      See identical proteins and their annotated locations for XP_011543816.1

      UniProtKB/Swiss-Prot
      O15480
      Related
      ENSP00000478513.1, ENST00000620842.1
      Conserved Domains (2) summary
      pfam01454
      Location:129286
      MAGE; MAGE family
      pfam12440
      Location:593
      MAGE_N; Melanoma associated antigen family N terminal
    2. XM_011545513.2XP_011543815.1  melanoma-associated antigen B3 isoform X1

      See identical proteins and their annotated locations for XP_011543815.1

      UniProtKB/Swiss-Prot
      O15480
      Conserved Domains (2) summary
      pfam01454
      Location:129286
      MAGE; MAGE family
      pfam12440
      Location:593
      MAGE_N; Melanoma associated antigen family N terminal

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      30279495..30286489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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