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    LCMT2 leucine carboxyl methyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 9836, updated on 8-Apr-2018
    Official Symbol
    LCMT2provided by HGNC
    Official Full Name
    leucine carboxyl methyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:17558
    See related
    Ensembl:ENSG00000168806 MIM:611246; Vega:OTTHUMG00000130705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPM2; TYW4
    Summary
    The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q15.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (43327776..43330622, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43619974..43622820, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk subunit d pseudogene 1 Neighboring gene transglutaminase 7 Neighboring gene adenosine deaminase like Neighboring gene zinc finger and SCAN domain containing 29 Neighboring gene tubulin gamma complex associated protein 4 Neighboring gene RNA, 7SL, cytoplasmic 487, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Synthesis of wybutosine at G37 of tRNA(Phe), organism-specific biosystem (from REACTOME)
      Synthesis of wybutosine at G37 of tRNA(Phe), organism-specific biosystemDerivatives of wyosine are tricyclic bases found at nucleotide 37 of tRNA(Phe) in eukaryotes. The pathway of wybutosine synthesis begins with a templated guanosine residue and proceeds through 6 step...
    • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
    • tRNA processing, organism-specific biosystem (from REACTOME)
      tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
    • wybutosine biosynthesis, organism-specific biosystem (from BIOCYC)
      wybutosine biosynthesis, organism-specific biosystem
      wybutosine biosynthesis
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC9534, FLJ51321, KIAA0547

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    S-adenosylmethionine-dependent methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein C-terminal leucine carboxyl O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tRNA methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    C-terminal protein methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tRNA modification TAS
    Traceable Author Statement
    more info
     
    wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    tRNA wybutosine-synthesizing protein 4
    Names
    p21WAF1/CIP1 promoter-interacting protein
    tRNA yW-synthesizing protein 4
    tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
    tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
    tRNA-Wybutosine-synthesizing protein 4
    NP_055608.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014793.4NP_055608.2  tRNA wybutosine-synthesizing protein 4

      See identical proteins and their annotated locations for NP_055608.2

      Status: REVIEWED

      Source sequence(s)
      BC015949, DB260484
      Consensus CDS
      CCDS10094.1
      UniProtKB/Swiss-Prot
      O60294
      Related
      ENSP00000307214.5, OTTHUMP00000161298, ENST00000305641.6, OTTHUMT00000253205
      Conserved Domains (2) summary
      pfam13415
      Location:493540
      Kelch_3; Galactose oxidase, central domain
      cl17173
      Location:28197
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      43327776..43330622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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