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    MAF1 MAF1 homolog, negative regulator of RNA polymerase III [ Homo sapiens (human) ]

    Gene ID: 84232, updated on 8-Apr-2018
    Official Symbol
    MAF1provided by HGNC
    Official Full Name
    MAF1 homolog, negative regulator of RNA polymerase IIIprovided by HGNC
    Primary source
    HGNC:HGNC:24966
    See related
    Ensembl:ENSG00000179632 MIM:610210; Vega:OTTHUMG00000165244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues See more
    Orthologs
    Location:
    8q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (144104402..144107612)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145159305..145162515)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cytochrome c1 Neighboring gene SHANK associated RH domain interactor Neighboring gene WD repeat domain 97 Neighboring gene HGH1 homolog

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC20332, MGC31779, MGC39758

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase III core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase III type 1 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase III type 2 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase III type 3 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    inhibitory synapse IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    repressor of RNA polymerase III transcription MAF1 homolog
    Names
    MAF1 negative regulator of RNA polymerase III
    homolog of yeast MAF1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032272.4NP_115648.2  repressor of RNA polymerase III transcription MAF1 homolog

      See identical proteins and their annotated locations for NP_115648.2

      Status: REVIEWED

      Source sequence(s)
      BC018714, BC031273, BE093055, BF339064, BM721318, DN997000
      Consensus CDS
      CCDS6416.1
      UniProtKB/Swiss-Prot
      Q9H063
      Related
      ENSP00000318604.5, OTTHUMP00000229044, ENST00000322428.9, OTTHUMT00000382910
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      144104402..144107612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013904.1XP_016869393.1  repressor of RNA polymerase III transcription MAF1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9H063
      Related
      ENSP00000436720.1, OTTHUMP00000229046, ENST00000532522.5, OTTHUMT00000382912
      Conserved Domains (1) summary
      pfam09174
      Location:25202
      Maf1; Maf1 regulator
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